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dc.contributor.authorAparicio García-Molina, Virginia 
dc.contributor.authorBaena García, Laura 
dc.contributor.authorDe la Flor Alemany, Marta 
dc.contributor.authorMartínez González, Luis Javier 
dc.contributor.authorVarela López, Alfonso 
dc.contributor.authorSánchez González, Cristina 
dc.contributor.authorQuiles Morales, José Luis
dc.identifier.citationAparicio VA... [et al.]. Differences in maternal and neonatal cardiometabolic markers and placenta status by foetal sex. The GESTAFIT project. Women’s Health. 2022;18. doi:[10.1177/17455057221117976]es_ES
dc.description.abstractAims: To explore the differences in some maternal-neonatal metabolic markers and placenta status by foetal sex. Methods: One hundred thirty-nine Caucasian pregnant women from the GESTAFIT project and their new-borns were included in the present cross-sectional study. Serum cardiometabolic markers (i.e. lipid and glycaemic profile and uric acid) were analysed at late pregnancy and at birth. In placenta, telomeres length, proportion of deleted mitochondrial-DNA and mitochondrial-DNA density, some minerals and interleukin 8, epidermal growth factor, fibroblast growth factor-2 and vascular endothelial growth factor were measured. The study was run between November 2015 and April 2018. Results: Mothers carrying a male showed higher serum triglycerides than mothers carrying a female at late pregnancy (p < .05). Serum total and low-density lipoprotein cholesterol were greater in males’ umbilical cord blood artery compared to females’ new-borns (both, p < .05). Mothers of males and male new-borns presented higher uric acid than mothers of females and female new-borns at birth (p < .05). Female’s placentas presented greater placental-newborn weight ratio, manganese content and fibroblast growth factor-2 (all, p ⩽ .05), and evidence of statistical significance in telomeres length, which were 17% longer (p = .076). Conclusion: Our findings show weak differences in some cardiometabolic and placental status markers by foetal sex. Notwithstanding, we observed a slightly more proatherogenic profile in both, mothers carrying males’ foetuses and male new-borns. We also found lower serum uric acid and better placenta status in mothers carrying a female. These findings indicate that foetal sex might need to be considered for a more personalized follow-up of pregnancies.es_ES
dc.description.sponsorshipRegional Ministry of Health, Junta de Andalucia PI-0395-2016es_ES
dc.description.sponsorshipUniversity of Granadaes_ES
dc.description.sponsorshipJunta de Andaluciaes_ES
dc.description.sponsorshipEuropean Commission SOMM17/6107/UGRes_ES
dc.description.sponsorshipPlan Propio de Investigacion 2016, Excellence actions (Units of Excellence: Unit of Excellence in Exercise and Health)es_ES
dc.rightsAtribución-NoComercial 4.0 Internacional*
dc.subjectFibroblast Growth Factores_ES
dc.titleDifferences in maternal and neonatal cardiometabolic markers and placenta status by foetal sex. The GESTAFIT projectes_ES

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Atribución-NoComercial 4.0 Internacional
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