Obesity and Bone Health: A Complex Relationship
Metadatos
Mostrar el registro completo del ítemAutor
Piñar Gutiérrez, Ana; García Fontana, Cristina; García Fontana, Beatriz; Muñoz Torres, Manuel EduardoEditorial
MDPI
Materia
Obesity Fracture Body composition Inflammation Healthy aging Osteoporosis
Fecha
2022-07-27Referencia bibliográfica
Piñar-Gutierrez, A... [et al.]. Obesity and Bone Health: A Complex Relationship. Int. J. Mol. Sci. 2022, 23, 8303. [https://doi.org/10.3390/ijms23158303]
Patrocinador
Instituto de Salud Carlos III; European Commission CD20/00022 PI18-00803 PI21-01069 PI18-01235; European Commission; Junta de Andalucia PI-0268-2019Resumen
Recent scientific evidence has shown an increased risk of fractures in patients with obesity,
especially in those with a higher visceral adipose tissue content. This contradicts the old paradigm
that obese patients were more protected than those with normal weight. Specifically, in older subjects
in whom there is a redistribution of fat from subcutaneous adipose tissue to visceral adipose tissue and
an infiltration of other tissues such as muscle with the consequent sarcopenia, obesity can accentuate
the changes characteristic of this age group that predisposes to a greater risk of falls and fractures.
Other factors that determine a greater risk in older subjects with obesity are chronic proinflammatory
status, altered adipokine secretion, vitamin D deficiency, insulin resistance and reduced mobility. On
the other hand, diagnostic tests may be influenced by obesity and its comorbidities as well as by body
composition, and risk scales may underestimate the risk of fractures in these patients. Weight loss
with physical activity programs and cessation of high-fat diets may reduce the risk. Finally, more
research is needed on the efficacy of anti-osteoporotic treatments in obese patients.