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dc.contributor.authorVázquez de Ágredos Martín Gil, Ana 
dc.contributor.authorGámiz Ruiz, Fernando 
dc.contributor.authorGallo Torre, Milagros
dc.identifier.citationVázquez-Ágredos A, Gámiz F and Gallo M (2022) MicroRNA Regulation of the Environmental Impact on Adolescent Neurobehavioral Development: A Systematic Review. Front. Cell. Neurosci. 16:956609. doi: [10.3389/fncel.2022.956609]es_ES
dc.description.abstractAdolescence is a late developmental period marked by pronounced reorganization of brain networks in which epigenetic mechanisms play a fundamental role. This brain remodeling is associated with a peculiar behavior characterized by novelty seeking and risky activities such as alcohol and drug abuse, which is associated with increased susceptibility to stress. Hence, adolescence is a vulnerable postnatal period since short- and long-term deleterious effects of alcohol drinking and drug abuse are a serious worldwide public health concern. Among several other consequences, it has been proposed that exposure to stress, alcohol, or other drugs disrupts epigenetic mechanisms mediated by small non-coding microRNAs (miRNAs). During adolescence, this modifies the expression of a variety of genes involved in neurodevelopmental processes such as proliferation, differentiation, synaptogenesis, neural plasticity, and apoptosis. Hence, the effect of miRNAs dysregulation during adolescence might contribute to a long-term impact on brain function. This systematic review focuses on the miRNA expression patterns in the adolescent rodent brain with special interest in the impact of stress and drugs such as amphetamine, cocaine, nicotine, cannabis, and ketamine. The results point to a relevant and complex role of miRNAs in the regulation of the molecular processes involved in adolescent brain development as part of a dynamic epigenetic network sensitive to environmental events with distinctive changes across adolescence. Several miRNAs have been assessed evidencing changing expression profiles during the adolescent transition which are altered by exposure to stress and drug abuse. Since this is an emerging rapidly growing field, updating the present knowledge will contribute to improving our understanding of the epigenetic regulation mechanisms involved in the neurodevelopmental changes responsible for adolescent behavior. It can be expected that increased knowledge of themolecularmechanismsmediating the effect of environmental threats during the adolescent critical developmental period will improve understanding of psychiatric and addictive disorders emerging at this stage.es_ES
dc.description.sponsorshipSpanish Government PID2020-114269GB-I00es_ES
dc.description.sponsorshipFEDER, Junta de Andalucia, Spain BSEJ.514.UGR20es_ES
dc.description.sponsorshipMIU, Spain FPU18/05012es_ES
dc.rightsAtribución 4.0 Internacional*
dc.subjectAlcohol es_ES
dc.subjectBehavior es_ES
dc.subjectBrain es_ES
dc.subjectStress es_ES
dc.titleMicroRNA Regulation of the Environmental Impact on Adolescent Neurobehavioral Development: A Systematic Reviewes_ES

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Atribución 4.0 Internacional
Except where otherwise noted, this item's license is described as Atribución 4.0 Internacional