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Metabolic Signatures of Healthy Lifestyle Patterns and Colorectal Cancer Risk in a European Cohort
dc.contributor.author | Rothwell, Joseph A. | |
dc.contributor.author | Sánchez Pérez, María José | |
dc.date.accessioned | 2022-07-18T11:34:38Z | |
dc.date.available | 2022-07-18T11:34:38Z | |
dc.date.issued | 2020-12-29 | |
dc.identifier.citation | Joseph A. Rothwell... [et al.]. Metabolic Signatures of Healthy Lifestyle Patterns and Colorectal Cancer Risk in a European Cohort, Clinical Gastroenterology and Hepatology, Volume 20, Issue 5, 2022, Pages e1061-e1082, ISSN 1542-3565, [https://doi.org/10.1016/j.cgh.2020.11.045] | es_ES |
dc.identifier.uri | http://hdl.handle.net/10481/76094 | |
dc.description.abstract | BACKGROUND & AIMS: Colorectal cancer risk can be lowered by adherence to the World Cancer Research Fund/ American Institute for Cancer Research (WCRF/AICR) guidelines. We derived metabolic signatures of adherence to these guidelines and tested their associations with colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition cohort. METHODS: Scores reflecting adherence to the WCRF/AICR recommendations (scale, 1–5) were calculated from participant data on weight maintenance, physical activity, diet, and alcohol among a discovery set of 5738 cancer-free European Prospective Investigation into Cancer and Nutrition participants with metabolomics data. Partial least-squares regression was used to derive fatty acid and endogenous metabolite signatures of the WCRF/AICR score in this group. In an independent set of 1608 colorectal cancer cases and matched controls, odds ratios (ORs) and 95% CIs were calculated for colorectal cancer risk per unit increase in WCRF/AICR score and per the corresponding change in metabolic signatures using multivariable conditional logistic regression. RESULTS: Higher WCRF/AICR scores were characterized by metabolic signatures of increased odd-chain fatty acids, serine, glycine, and specific phosphatidylcholines. Signatures were inversely associated more strongly with colorectal cancer risk (fatty acids: OR, 0.51 per unit increase; 95% CI, 0.29–0.90; endogenous metabolites: OR, 0.62 per unit change; 95% CI, 0.50–0.78) than the WCRF/AICR score (OR, 0.93 per unit change; 95% CI, 0.86–1.00) overall. Signature associations were stronger in male compared with female participants. CONCLUSIONS: Metabolite profiles reflecting adherence to WCRF/AICR guidelines and additional lifestyle or biological risk factors were associated with colorectal cancer. Measuring a specific panel of metabolites representative of a healthy or unhealthy lifestyle may identify strata of the population at higher risk of colorectal cancer. | es_ES |
dc.description.sponsorship | World Cancer Research Fund International (WCRF) 20131002 | es_ES |
dc.description.sponsorship | European Commission grant EU-FP7/BBMRI-LPC 313010 | es_ES |
dc.description.sponsorship | International Agency for Research on Cancer | es_ES |
dc.description.sponsorship | Danish Cancer Society | es_ES |
dc.description.sponsorship | Ligue Contre le Cancer (France) | es_ES |
dc.description.sponsorship | General Electric | es_ES |
dc.description.sponsorship | Institut Gustave-Roussy (France) | es_ES |
dc.description.sponsorship | Mutuelle Generale de l'Education Nationale (France) | es_ES |
dc.description.sponsorship | Institut National de la Sante et de la Recherche Medicale (Inserm) | es_ES |
dc.description.sponsorship | Deutsche Krebshilfe German Cancer Research Center (Germany) Federal Ministry of Education & Research (BMBF) Deutsche Krebshilfe | es_ES |
dc.description.sponsorship | Hellenic Health Foundation (Greece) | es_ES |
dc.description.sponsorship | Fondazione AIRC per la ricerca sul cancro | es_ES |
dc.description.sponsorship | Consiglio Nazionale delle Ricerche (CNR) | es_ES |
dc.description.sponsorship | Dutch Ministry of Public Health, Welfare and Sports (The Netherlands) Netherlands Cancer Registry (The Netherlands) Netherlands Government | es_ES |
dc.description.sponsorship | Nordic Centre of Excellence Programme on Food, Nutrition and Health (Norway) | es_ES |
dc.description.sponsorship | Instituto de Salud Carlos III PI13/00061 PI13/01162 | es_ES |
dc.description.sponsorship | Junta de Andalucia | es_ES |
dc.description.sponsorship | Basque Government | es_ES |
dc.description.sponsorship | Regional Government of Murcia | es_ES |
dc.description.sponsorship | Regional Government of Navarra | es_ES |
dc.description.sponsorship | Instituto de Salud Carlos III Cooperative Research in Health (Spain) RD06/0020 | es_ES |
dc.description.sponsorship | Swedish Cancer Society Swedish Research Council | es_ES |
dc.description.sponsorship | County Council of Skane (Sweden) County Council of Vasterbotten (Sweden) | es_ES |
dc.description.sponsorship | Cancer Research UK 14136 C570/A16491 C8221/A19170 | es_ES |
dc.description.sponsorship | UK Research & Innovation (UKRI) | es_ES |
dc.description.sponsorship | Medical Research Council UK (MRC) 1000143 MR/M012190/1 | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Elsevier | es_ES |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Colorectal neoplasm | es_ES |
dc.subject | Risk factors | es_ES |
dc.subject | World Cancer Research Fund/American Institute for Cancer Research Recommendations | es_ES |
dc.subject | Targeted metabolomics | es_ES |
dc.title | Metabolic Signatures of Healthy Lifestyle Patterns and Colorectal Cancer Risk in a European Cohort | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/EC/FP7/313010 | es_ES |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es_ES |
dc.identifier.doi | 10.1016/j.cgh.2020.11.045 | |
dc.type.hasVersion | info:eu-repo/semantics/publishedVersion | es_ES |
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