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dc.contributor.authorAguilera Garrido, Aixa María 
dc.contributor.authorGálvez Ruiz, María José 
dc.contributor.authorMarchal Corrales, Juan Antonio 
dc.contributor.authorGalisteo González, Francisco
dc.identifier.citationAixa Aguilera-Garrido... [et al.] (2022) Solid lipid nanoparticles to improve bioaccessibility and permeability of orally administered maslinic acid, Drug Delivery, 29:1, 1971-1982, DOI: [10.1080/10717544.2022.2086937]es_ES
dc.description.abstractMaslinic acid (MA) is a plant-derived, low water-soluble compound with antitumor activity. We have formulated MA in the form of solid lipid nanoparticles (SLNs) with three different shell compositions: Poloxamer 407 (PMA), dicarboxylic acid-Poloxamer 407 (PCMA), and HA-coated PCMA (PCMA-HA). These SLNs improved the solubility of MA up to 7.5mg/mL, are stable in a wide range of pH, and increase the bioaccessibility of MA after in vitro gastrointestinal (GI) digestion. Gastrointestinal digested SLNs afforded MA delivery across in vitro gut barrier models (21 days old Caco-2 and mucus-producing Caco-2/HT29-MTX co-cultures). The cellular fraction of Caco-2/HT29-MTX co-cultures retained more MA from GI digested PCMA-HA than the Caco-2 monolayers. The concentration of MA reached in the basolateral chamber inhibited growth of pancreatic cancer cells, BxPC3. Finally, confocal microscopy images provided evidence that Nile Red incorporated in MA SLNs was capable of crossing Caco-2 monolayers to be taken up by basolaterally located BxPC3 cells. We have demonstrated that SLNs can be used as nanocarriers of hydrophobic antitumor compounds and that these SLNs are suitable for oral consumption and delivery of the bioactive across the gut barrier.es_ES
dc.description.sponsorshipMinisterio de Ciencia e Innovacion (MCIN/AEI/FEDER) RTI2018-101309-B-C21 RTI2018-101309-B-C22es_ES
dc.description.sponsorshipEuropean Molecular Biology Organization (EMBO-short term fellowships) 8475es_ES
dc.description.sponsorshipEnterprise Ireland (Career-FIT)es_ES
dc.description.sponsorshipEuropean Commission 713654es_ES
dc.description.sponsorshipMF2018-0151 Food-BIBSes_ES
dc.description.sponsorshipScience Foundation Irelandes_ES
dc.description.sponsorshipDepartment of Agriculture, Food and Marine on behalf of the Government of Ireland 16/RC/3835es_ES
dc.description.sponsorshipEuropean Commission European Commission Joint Research Centre European Regional Development Funds of the Junta de Andaluciaes_ES
dc.description.sponsorshipSpanish Governmentes_ES
dc.publisherTaylor & Francises_ES
dc.rightsAtribución 4.0 Internacional*
dc.subjectSolid lipid nanoparticlees_ES
dc.subjectMaslinic acides_ES
dc.subjectDigestion es_ES
dc.subjectIntestinal permeabilityes_ES
dc.titleSolid lipid nanoparticles to improve bioaccessibility and permeability of orally administered maslinic acides_ES

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Atribución 4.0 Internacional
Except where otherwise noted, this item's license is described as Atribución 4.0 Internacional