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Zirconium Metal−Organic Polyhedra with Dual Behavior for Organophosphate Poisoning Treatment
dc.contributor.author | Delgado López, Pedro José | |
dc.contributor.author | Martín Romera, Javier David | |
dc.contributor.author | Perona, Cristina | |
dc.contributor.author | Vismara, Rebecca | |
dc.contributor.author | Rodríguez Maldonado, Carmen | |
dc.contributor.author | Carmona Fernández, Francisco Jesús | |
dc.contributor.author | Rodríguez Navarro, Jorge Andrés | |
dc.date.accessioned | 2022-07-06T08:27:29Z | |
dc.date.available | 2022-07-06T08:27:29Z | |
dc.date.issued | 2022-06-02 | |
dc.identifier.citation | ACS Appl. Mater. Interfaces 2022, 14, 26501−26506. [https://doi.org/10.1021/acsami.2c06025] | es_ES |
dc.identifier.uri | http://hdl.handle.net/10481/75842 | |
dc.description.abstract | Organophosphate nerve agents and pesticides are extremely toxic compounds because they result in acetylcholinesterase (AChE) inhibition and concomitant nerve system damage. Herein, we report the synthesis, structural characterization, and proof-of-concept utility of zirconium metal−organic polyhedra (Zr-MOPs) for organophosphate poisoning treatment. The results show the formation of robust tetrahedral cages [((n-butylCpZr)3(OH)3O)4L6]Cl6 (Zr-MOP-1; L = benzene-1,4- dicarboxylate, n-butylCp = n-butylcyclopentadienyl, Zr-MOP-10, and L = 4,4′-biphenyldicarboxylate) decorated with lipophilic alkyl residues and possessing accessible cavities of ∼9.8 and ∼10.7 Å inner diameters, respectively. These systems are able to both capture the organophosphate model compound diisopropylfluorophosphate (DIFP) and host and release the AChE reactivator drug pralidoxime (2-PAM). The resulting 2-PAM@ Zr-MOP-1(0) host−guest assemblies feature a sustained delivery of 2-PAM under simulated biological conditions, with a concomitant reactivation of DIFP-inhibited AChE. Finally, 2-PAM@Zr-MOP systems have been incorporated into biocompatible phosphatidylcholine liposomes with the resulting assemblies being non-neurotoxic, as proven using neuroblastoma cell viability assays. | es_ES |
dc.description.sponsorship | Spanish MCIN/AEI PID2020-113608RB-I00 | es_ES |
dc.description.sponsorship | FEDER/Junta de Andalucia-Conserjeria de Economia y Conocimiento B-FQM-364-UGR18 B-FQM-006-UGR18 | es_ES |
dc.description.sponsorship | FEDER/Junta de Andalucia-Consejeria de Transformacion Economica, Industria, Conocimiento y Universidades P18-RT-612 P20_00672 | es_ES |
dc.description.sponsorship | Fondazione CRUI | es_ES |
dc.description.sponsorship | programa Juan de la Cierva Formacion | es_ES |
dc.description.sponsorship | Spanish Government PID2020-118117RB-I00 | es_ES |
dc.description.sponsorship | Center for Forestry Research & Experimentation (CIEF) | es_ES |
dc.description.sponsorship | European Commission SEJIGENT/2021/059 PROMETEU/2021/054 | es_ES |
dc.description.sponsorship | La Caixa Foundation 100010434 LCF/BQ/PR20/11770014 | es_ES |
dc.description.sponsorship | "Maria de Maeztu" Program for Centers of Excellence in RD CEX2019-000919-M | es_ES |
dc.description.sponsorship | H2020-MSCA-IF2019-888972-PSust-MOF | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | American Chemical Society | es_ES |
dc.rights | Atribución 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject | Nerve agents | es_ES |
dc.subject | Host-guest chemistry | es_ES |
dc.subject | Pesticide | es_ES |
dc.subject | Controlled drug delivery | es_ES |
dc.subject | Metal-organic cages | es_ES |
dc.title | Zirconium Metal−Organic Polyhedra with Dual Behavior for Organophosphate Poisoning Treatment | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/EC/H2020/888972 | es_ES |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es_ES |
dc.identifier.doi | 10.1021/acsami.2c06025 | |
dc.type.hasVersion | info:eu-repo/semantics/publishedVersion | es_ES |
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