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dc.contributor.authorDelgado López, Pedro José 
dc.contributor.authorMartín Romera, Javier David 
dc.contributor.authorPerona, Cristina
dc.contributor.authorVismara, Rebecca 
dc.contributor.authorRodríguez Maldonado, Carmen 
dc.contributor.authorCarmona Fernández, Francisco Jesús 
dc.contributor.authorRodríguez Navarro, Jorge Andrés 
dc.date.accessioned2022-07-06T08:27:29Z
dc.date.available2022-07-06T08:27:29Z
dc.date.issued2022-06-02
dc.identifier.citationACS Appl. Mater. Interfaces 2022, 14, 26501−26506. [https://doi.org/10.1021/acsami.2c06025]es_ES
dc.identifier.urihttp://hdl.handle.net/10481/75842
dc.description.abstractOrganophosphate nerve agents and pesticides are extremely toxic compounds because they result in acetylcholinesterase (AChE) inhibition and concomitant nerve system damage. Herein, we report the synthesis, structural characterization, and proof-of-concept utility of zirconium metal−organic polyhedra (Zr-MOPs) for organophosphate poisoning treatment. The results show the formation of robust tetrahedral cages [((n-butylCpZr)3(OH)3O)4L6]Cl6 (Zr-MOP-1; L = benzene-1,4- dicarboxylate, n-butylCp = n-butylcyclopentadienyl, Zr-MOP-10, and L = 4,4′-biphenyldicarboxylate) decorated with lipophilic alkyl residues and possessing accessible cavities of ∼9.8 and ∼10.7 Å inner diameters, respectively. These systems are able to both capture the organophosphate model compound diisopropylfluorophosphate (DIFP) and host and release the AChE reactivator drug pralidoxime (2-PAM). The resulting 2-PAM@ Zr-MOP-1(0) host−guest assemblies feature a sustained delivery of 2-PAM under simulated biological conditions, with a concomitant reactivation of DIFP-inhibited AChE. Finally, 2-PAM@Zr-MOP systems have been incorporated into biocompatible phosphatidylcholine liposomes with the resulting assemblies being non-neurotoxic, as proven using neuroblastoma cell viability assays.es_ES
dc.description.sponsorshipSpanish MCIN/AEI PID2020-113608RB-I00es_ES
dc.description.sponsorshipFEDER/Junta de Andalucia-Conserjeria de Economia y Conocimiento B-FQM-364-UGR18 B-FQM-006-UGR18es_ES
dc.description.sponsorshipFEDER/Junta de Andalucia-Consejeria de Transformacion Economica, Industria, Conocimiento y Universidades P18-RT-612 P20_00672es_ES
dc.description.sponsorshipFondazione CRUIes_ES
dc.description.sponsorshipprograma Juan de la Cierva Formaciones_ES
dc.description.sponsorshipSpanish Government PID2020-118117RB-I00es_ES
dc.description.sponsorshipCenter for Forestry Research & Experimentation (CIEF)es_ES
dc.description.sponsorshipEuropean Commission SEJIGENT/2021/059 PROMETEU/2021/054es_ES
dc.description.sponsorshipLa Caixa Foundation 100010434 LCF/BQ/PR20/11770014es_ES
dc.description.sponsorship"Maria de Maeztu" Program for Centers of Excellence in RD CEX2019-000919-Mes_ES
dc.description.sponsorshipH2020-MSCA-IF2019-888972-PSust-MOFes_ES
dc.language.isoenges_ES
dc.publisherAmerican Chemical Societyes_ES
dc.rightsAtribución 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectNerve agentses_ES
dc.subjectHost-guest chemistryes_ES
dc.subjectPesticide es_ES
dc.subjectControlled drug deliveryes_ES
dc.subjectMetal-organic cageses_ES
dc.titleZirconium Metal−Organic Polyhedra with Dual Behavior for Organophosphate Poisoning Treatmentes_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/H2020/888972es_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES
dc.identifier.doi10.1021/acsami.2c06025
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersiones_ES


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