Show simple item record

dc.contributor.authorOrtiz González, Matilde
dc.contributor.authorPérez Victoria, Ignacio
dc.contributor.authorRamírez Macías, Inmaculada
dc.contributor.authorDe Pedro, Nuria
dc.contributor.authorLinde Rodríguez, Ángel
dc.contributor.authorGonzález Menéndez, Victor M.
dc.contributor.authorSánchez Martín, Victoria
dc.contributor.authorMartín, Jesús
dc.contributor.authorSoriano Lerma, Ana del Carmen 
dc.contributor.authorGenilloud, Olga
dc.contributor.authorPérez Carrasco, Virginia
dc.contributor.authorVicente, Francisca
dc.contributor.authorMaceira, José
dc.contributor.authorRodrígues Poveda, Carlos Alberto
dc.contributor.authorNavarro Marí, José María
dc.contributor.authorReyes, Fernando
dc.contributor.authorSoriano, Miguel
dc.contributor.authorGarcía Salcedo, José Antonio
dc.identifier.citationOrtiz-Gonzalez, M... [et al.]. Curvicollide D Isolated from the Fungus Amesia sp. Kills African Trypanosomes by Inhibiting Transcription. Int. J. Mol. Sci. 2022, 23, 6107. []es_ES
dc.description.abstractSleeping sickness or African trypanosomiasis is a serious health concern with an added socio-economic impact in sub-Saharan Africa due to direct infection in both humans and their domestic livestock. There is no vaccine available against African trypanosomes and its treatment relies only on chemotherapy. Although the current drugs are effective, most of them are far from the modern concept of a drug in terms of toxicity, specificity and therapeutic regime. In a search for new molecules with trypanocidal activity, a high throughput screening of 2000 microbial extracts was performed. Fractionation of one of these extracts, belonging to a culture of the fungus Amesia sp., yielded a new member of the curvicollide family that has been designated as curvicollide D. The new compound showed an inhibitory concentration 50 (IC50) 16-fold lower in Trypanosoma brucei than in human cells. Moreover, it induced cell cycle arrest and disruption of the nucleolar structure. Finally, we showed that curvicollide D binds to DNA and inhibits transcription in African trypanosomes, resulting in cell death. These results constitute the first report on the activity and mode of action of a member of the curvicollide family in T. brucei.es_ES
dc.description.sponsorshipEuropean Union (Euronanomed programme, Reference: TARBRAINFECT)es_ES
dc.description.sponsorshipHealth Carlos III as the local management institution AC18/00008es_ES
dc.description.sponsorshipMinistry of Science, Innovation and Universities from Spain PID2020-120481RB-I00es_ES
dc.description.sponsorshipMinistry of Education, Culture and Sport FPU 17/05413 FPU 16/05822 FPU 20/03952es_ES
dc.description.sponsorshipUniversity of Almeria FPI-201102 PPUENTE2021-006es_ES
dc.rightsAtribución 4.0 Internacional*
dc.subjectAfrican trypanosomiasises_ES
dc.subjectNatural productses_ES
dc.subjectNew trypanocidal moleculees_ES
dc.subjectCurvicollide Des_ES
dc.titleCurvicollide D Isolated from the Fungus Amesia sp. Kills African Trypanosomes by Inhibiting Transcriptiones_ES

Files in this item


This item appears in the following Collection(s)

Show simple item record

Atribución 4.0 Internacional
Except where otherwise noted, this item's license is described as Atribución 4.0 Internacional