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dc.contributor.authorMartín Escolano, Javier
dc.contributor.authorMarín Sánchez, Clotilde 
dc.contributor.authorRosales Lombardo, María José 
dc.contributor.authorMedina Carmona, Encarnación 
dc.date.accessioned2022-06-29T09:12:18Z
dc.date.available2022-06-29T09:12:18Z
dc.date.issued2022-06-02
dc.identifier.citationACS Infect. Dis. 2022, 8, 6, 1107–1115. [https://doi.org/10.1021/acsinfecdis.2c00123]es_ES
dc.identifier.urihttp://hdl.handle.net/10481/75714
dc.description.abstractChagas disease (CD) is a parasitic, systemic, chronic, and often fatal illness caused by infection with the protozoan Trypanosoma cruzi. The World Health Organization classifies CD as the most prevalent of povertypromoting neglected tropical diseases, the most important parasitic one, and the third most infectious disease in Latin America. Currently, CD is a global public health issue that affects 6−8 million people. However, the current approved treatments are limited to two nitroheterocyclic drugs developed more than 50 years ago. Many efforts have been made in recent decades to find new therapies, but our limited understanding of the infection process, pathology development, and long-term nature of this disease has made it impossible to develop new drugs, effective treatment, or vaccines. This Review aims to provide a comprehensive update on our understanding of the current life cycle, new morphological forms, and genetic diversity of T. cruzi, as well as identify intervention points in the life cycle where new drugs and treatments could achieve a parasitic cure.es_ES
dc.description.sponsorshipJunta de Andalucia E-BIO-464-UGR20es_ES
dc.description.sponsorshipJunta de Andalucia (Proyectos I+D+I FEDER Andalucia 2014-2020)es_ES
dc.description.sponsorshipAlfonso Martin Escudero Foundationes_ES
dc.language.isoenges_ES
dc.publisherAmerican Chemical Societyes_ES
dc.rightsAtribución 3.0 España*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es/*
dc.subjectChagas diseasees_ES
dc.subjectDrug discoveryes_ES
dc.subjectEvolution modeles_ES
dc.subjectGenetic diversityes_ES
dc.subjectLife cyclees_ES
dc.subjectMorphological formses_ES
dc.subjectTarget product profilees_ES
dc.subjectTropismes_ES
dc.subjectTrypanosoma cruzies_ES
dc.titleAn Updated View of the Trypanosoma cruzi Life Cycle: Intervention Points for an Effective Treatmentes_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES
dc.identifier.doi10.1021/acsinfecdis.2c00123
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersiones_ES


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Atribución 3.0 España
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