Association of blood trihalomethane concentrations with asthma in US adolescents: nationally representative cross-sectional study
Metadatos
Mostrar el registro completo del ítemEditorial
European Respiratory Society
Fecha
2022-05-26Referencia bibliográfica
Sun Y... [et al.]. Association of blood trihalomethane concentrations with asthma in US adolescents: nationally representative cross-sectional study. Eur Respir J 2022; 59: 2101440 DOI: [10.1183/13993003.01440-2021]
Patrocinador
National Natural Science Foundation of China (NSFC) 81903281; United States Department of Health & Human Services National Institutes of Health (NIH) - USA NIH National Institute of Environmental Health Sciences (NIEHS) R01ES031657Resumen
Background Population studies show that the use of swimming pools is associated with the risk of asthma
and allergic diseases among children. Our objective was to explore the associations between blood
trihalomethane (THM) concentrations and asthma among US adolescents, and assess to what extent the
association is modified by active tobacco smoke exposure.
Methods We included 2359 adolescents aged 12–19 years with measured blood concentrations of
chloroform (trichloromethane (TCM)), bromodichloromethane (BDCM), dibromochloromethane (DBCM)
and bromoform (tribromomethane (TBM)) from the National Health and Nutrition Examination Survey
2005–2012. Logistic regression models were fitted to assess the odds ratios for the association of
blood THM concentrations (three or four categories) with the risk of self-reported current and ever
(lifetime) asthma.
Results Blood DBCM concentrations were associated with a higher risk of ever asthma among all
adolescents (OR 1.54 (95% CI 1.07–2.21), comparing the extreme exposure categories). The relationship
was stronger among adolescents exposed to tobacco smoke (OR 3.96 (95% CI 1.89–8.30), comparing the
extreme exposure categories). We also found positive relationships between blood brominated
THM concentrations (sum of BDCM, DBCM and TBM) and risk of ever asthma and between
blood DBCM and brominated THM concentrations and risk of current asthma among adolescents with
tobacco smoke exposure. The relative excess risk of ever asthma due to the interaction between high blood
DBCM and brominated THM concentrations and tobacco smoke exposure was 1.87 (95% CI 0.30–3.43)
and 0.78 (95% CI 0.07–1.49), respectively.
Conclusions Exposure to THMs is associated with a higher risk of asthma in adolescents, particularly
among those exposed to tobacco smoke.