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dc.contributor.authorMurtazina, Alima
dc.contributor.authorRuiz Alcalá, Gloria
dc.contributor.authorJiménez Martínez, Yaiza
dc.contributor.authorMarchal Corrales, Juan Antonio 
dc.contributor.authorBoulaiz Tassi, Houria 
dc.date.accessioned2022-06-27T08:33:24Z
dc.date.available2022-06-27T08:33:24Z
dc.date.issued2022-05-20
dc.identifier.citationMurtazina, A... [et al.]. Anti-Cancerous Potential of Polysaccharides Derived from Wheat Cell Culture. Pharmaceutics 2022, 14, 1100. [https://doi.org/10.3390/pharmaceutics14051100]es_ES
dc.identifier.urihttp://hdl.handle.net/10481/75672
dc.description.abstractThere is a global need to discover effective anti-cancerous compounds from natural sources. Cultivated wheat cells can be a valuable source of non-toxic or low toxic plant-derived polysaccharides. In this study, we evaluated the anti-cancer ability of seven fractions of wheat cell culture polysaccharides (WCCPSs) in the HCT-116 colon cancer cell line. Almost all (6/7) fractions had an inhibitory effect on the proliferation of colon cancer cells, and two fractions (A-b and A-f) had considerable therapeutic indexes. The WCCPS fractions induced cell cycle arrest in the G1 phase and induced different rates of apoptosis ( 48%). Transmission and scanning electron microscopy revealed that WCCPS fractions caused apoptotic changes in the nucleus and cytoplasm, including damage to mitochondria and external morphological signs of apoptosis. In addition, the WCCPSs induced an increase in the levels of Bax, cytochrome c, and caspases 8 and 3, indicating that cell death progressed through intrinsic and extrinsic pathways of apoptosis. Furthermore, some fractions caused a significant decrease of c-Myc, b-catenin, NFkB2, and HCAM (CD 44) levels, indicating enhanced cell differentiation. Thus, for the first time, our results provide a proof of concept of the anti-cancer capacity of WCCPS fractions in colorectal cancer.es_ES
dc.description.sponsorshipFEDER Operational Program 2020/Junta de AndaluciaConsejeria de Economia y Conocimiento/Project B-CTS-562-UGR20es_ES
dc.description.sponsorshipChair "Doctors GaleraRequena in cancer stem cell research" CMC-CTS963es_ES
dc.description.sponsorshipErasmus+ Mobility Programes_ES
dc.description.sponsorshipRepublic of Kazakhstanes_ES
dc.description.sponsorshipScottish Government's Rural and Environment Science and Analytical Services (RESAS) divisiones_ES
dc.language.isoenges_ES
dc.publisherMDPIes_ES
dc.rightsAtribución 3.0 España*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es/*
dc.subjectWheat cell culturees_ES
dc.subjectPlant polysaccharideses_ES
dc.subjectColon cancer cellses_ES
dc.subjectInhibition of proliferationes_ES
dc.subjectElectron microscopy es_ES
dc.subjectApoptosises_ES
dc.subjectCytochrome ces_ES
dc.subjectDifferentiationes_ES
dc.titleAnti-Cancerous Potential of Polysaccharides Derived from Wheat Cell Culturees_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES
dc.identifier.doi10.3390/pharmaceutics14051100
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersiones_ES


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Atribución 3.0 España
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