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Targeting HIF-1 alpha Function in Cancer through the Chaperone Action of NQO1: Implications of Genetic Diversity of NQO1
dc.contributor.author | Salido, Eduardo | |
dc.contributor.author | Palomino Morales, Rogelio Jesús | |
dc.contributor.author | Pacheco García, Juan Luis | |
dc.contributor.author | Pey Rodríguez, Ángel Luis | |
dc.date.accessioned | 2022-06-14T12:42:00Z | |
dc.date.available | 2022-06-14T12:42:00Z | |
dc.date.issued | 2022-05-05 | |
dc.identifier.citation | Salido, E... [et al.]. Targeting HIF-1alpha Function in Cancer through the Chaperone Action of NQO1: Implications of Genetic Diversity of NQO1. J. Pers. Med. 2022, 12, 747. [https://doi.org/10.3390/jpm12050747] | es_ES |
dc.identifier.uri | http://hdl.handle.net/10481/75488 | |
dc.description | This research was funded by the ERDF/Spanish Ministry of Science, Innovation and Universities-State Research Agency (Grant RTI2018-096246-B-I00, to A.L.P., PID2019-110900GBI00 to M.M. and SAF2015-69796 to E.S.), Consejeriia de Economiia, Conocimiento, Empresas y Universidad, Junta de Andalucia (Grant P18-RT-2413, to A.L.P.), and the Government of AragonFEDER (Grant E35-20R to M.M.). | es_ES |
dc.description.abstract | HIF-1 alpha is a master regulator of oxygen homeostasis involved in different stages of cancer development. Thus, HIF-1 alpha inhibition represents an interesting target for anti-cancer therapy. It was recently shown that the HIF-1 alpha interaction with NQO1 inhibits proteasomal degradation of the former, thus suggesting that targeting the stability and/or function of NQO1 could lead to the destabilization of HIF-1 alpha as a therapeutic approach. Since the molecular interactions of NQO1 with HIF-1 alpha are beginning to be unraveled, in this review we discuss: (1) Structure-function relationships of HIF-1 alpha; (2) our current knowledge on the intracellular functions and stability of NQO1; (3) the pharmacological modulation of NQO1 by small ligands regarding function and stability; (4) the potential effects of genetic variability of NQO1 in HIF-1 alpha levels and function; (5) the molecular determinants of NQO1 as a chaperone of many different proteins including cancer-associated factors such as HIF-1 alpha, p53 and p73 alpha. This knowledge is then further discussed in the context of potentially targeting the intracellular stability of HIF-1 alpha by acting on its chaperone, NQO1. This could result in novel anti-cancer therapies, always considering that the substantial genetic variability in NQO1 would likely result in different phenotypic responses among individuals. | es_ES |
dc.description.sponsorship | ERDF/Spanish Ministry of Science, Innovation and Universities-State Research Agency RTI2018-096246-B-I00 PID2019-110900GBI00 SAF2015-69796 | es_ES |
dc.description.sponsorship | Junta de Andalucia P18-RT-2413 | es_ES |
dc.description.sponsorship | Government of AragonFEDER E35-20R | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | MDPI | es_ES |
dc.rights | Atribución 3.0 España | * |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
dc.subject | HIF-1alpha | es_ES |
dc.subject | NQO1 | es_ES |
dc.subject | Hypoxia | es_ES |
dc.subject | Angiogenesis | es_ES |
dc.subject | Cancer | es_ES |
dc.subject | Protein: protein interactions | es_ES |
dc.subject | Ligand binding | es_ES |
dc.subject | Proteasomal degradation | es_ES |
dc.subject | Genetic variability | es_ES |
dc.title | Targeting HIF-1 alpha Function in Cancer through the Chaperone Action of NQO1: Implications of Genetic Diversity of NQO1 | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es_ES |
dc.identifier.doi | 10.3390/jpm12050747 | |
dc.type.hasVersion | info:eu-repo/semantics/publishedVersion | es_ES |