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dc.contributor.authorSalido, Eduardo
dc.contributor.authorPalomino Morales, Rogelio Jesús 
dc.contributor.authorPacheco García, Juan Luis 
dc.contributor.authorPey Rodríguez, Ángel Luis
dc.identifier.citationSalido, E... [et al.]. Targeting HIF-1alpha Function in Cancer through the Chaperone Action of NQO1: Implications of Genetic Diversity of NQO1. J. Pers. Med. 2022, 12, 747. []es_ES
dc.descriptionThis research was funded by the ERDF/Spanish Ministry of Science, Innovation and Universities-State Research Agency (Grant RTI2018-096246-B-I00, to A.L.P., PID2019-110900GBI00 to M.M. and SAF2015-69796 to E.S.), Consejeriia de Economiia, Conocimiento, Empresas y Universidad, Junta de Andalucia (Grant P18-RT-2413, to A.L.P.), and the Government of AragonFEDER (Grant E35-20R to M.M.).es_ES
dc.description.abstractHIF-1 alpha is a master regulator of oxygen homeostasis involved in different stages of cancer development. Thus, HIF-1 alpha inhibition represents an interesting target for anti-cancer therapy. It was recently shown that the HIF-1 alpha interaction with NQO1 inhibits proteasomal degradation of the former, thus suggesting that targeting the stability and/or function of NQO1 could lead to the destabilization of HIF-1 alpha as a therapeutic approach. Since the molecular interactions of NQO1 with HIF-1 alpha are beginning to be unraveled, in this review we discuss: (1) Structure-function relationships of HIF-1 alpha; (2) our current knowledge on the intracellular functions and stability of NQO1; (3) the pharmacological modulation of NQO1 by small ligands regarding function and stability; (4) the potential effects of genetic variability of NQO1 in HIF-1 alpha levels and function; (5) the molecular determinants of NQO1 as a chaperone of many different proteins including cancer-associated factors such as HIF-1 alpha, p53 and p73 alpha. This knowledge is then further discussed in the context of potentially targeting the intracellular stability of HIF-1 alpha by acting on its chaperone, NQO1. This could result in novel anti-cancer therapies, always considering that the substantial genetic variability in NQO1 would likely result in different phenotypic responses among individuals.es_ES
dc.description.sponsorshipERDF/Spanish Ministry of Science, Innovation and Universities-State Research Agency RTI2018-096246-B-I00 PID2019-110900GBI00 SAF2015-69796es_ES
dc.description.sponsorshipJunta de Andalucia P18-RT-2413es_ES
dc.description.sponsorshipGovernment of AragonFEDER E35-20Res_ES
dc.rightsAtribución 3.0 España*
dc.subjectCancer es_ES
dc.subjectProtein: protein interactionses_ES
dc.subjectLigand bindinges_ES
dc.subjectProteasomal degradationes_ES
dc.subjectGenetic variabilityes_ES
dc.titleTargeting HIF-1 alpha Function in Cancer through the Chaperone Action of NQO1: Implications of Genetic Diversity of NQO1es_ES

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Atribución 3.0 España
Except where otherwise noted, this item's license is described as Atribución 3.0 España