In utero exposure to bisphenols and asthma, wheeze, and lung function in school-age children: a prospective meta-analysis of 8 European birth cohorts
Metadatos
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Elsevier
Materia
Bisphenol A Pregnancy Asthma Wheezing Lung function Mother-child cohort
Fecha
2022-03-18Referencia bibliográfica
Alicia Abellan... [et al.]. In utero exposure to bisphenols and asthma, wheeze, and lung function in school-age children: a prospective meta-analysis of 8 European birth cohorts, Environment International, Volume 162, 2022, 107178, ISSN 0160-4120, [https://doi.org/10.1016/j.envint.2022.107178]
Patrocinador
Instituto de Salud Carlos III; European Commission European Commission CP16/ 00128 PI17/01194 308,333 European Commission European Commission Joint Research Centre 874,583Resumen
Background: In utero exposure to bisphenols, widely used in consumer products, may alter lung development and
increase the risk of respiratory morbidity in the offspring. However, evidence is scarce and mostly focused on
bisphenol A (BPA) only.
Objective: To examine the associations of in utero exposure to BPA, bisphenol F (BPF), and bisphenol S (BPS) with
asthma, wheeze, and lung function in school-age children, and whether these associations differ by sex. Methods: We included 3,007 mother–child pairs from eight European birth cohorts. Bisphenol concentrations
were determined in maternal urine samples collected during pregnancy (1999–2010). Between 7 and 11 years of
age, current asthma and wheeze were assessed from questionnaires and lung function by spirometry. Wheezing
patterns were constructed from questionnaires from early to mid-childhood. We performed adjusted randomeffects
meta-analysis on individual participant data.
Results: Exposure to BPA was prevalent with 90% of maternal samples containing concentrations above detection
limits. BPF and BPS were found in 27% and 49% of samples. In utero exposure to BPA was associated with higher
odds of current asthma (OR = 1.13, 95% CI = 1.01, 1.27) and wheeze (OR = 1.14, 95% CI = 1.01, 1.30) (pinteraction
sex = 0.01) among girls, but not with wheezing patterns nor lung function neither in overall nor
among boys. We observed inconsistent associations of BPF and BPS with the respiratory outcomes assessed in
overall and sex-stratified analyses.
Conclusion: This study suggests that in utero BPA exposure may be associated with higher odds of asthma and
wheeze among school-age girls.