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dc.contributor.authorNieto Ruiz, Ana María 
dc.contributor.authorGarcía Santos, José Antonio 
dc.contributor.authorVerdejo Román, Juan 
dc.contributor.authorDiéguez Castillo, Estefanía 
dc.contributor.authorHermann, Florian
dc.contributor.authorCerdó, Tomás
dc.contributor.authorGarcía Bermúdez, María Mercedes 
dc.contributor.authorPérez García, Miguel 
dc.contributor.authorMiranda León, María Teresa 
dc.contributor.authorCatena Martínez, Andrés 
dc.contributor.authorCampoy Folgoso, Cristina 
dc.date.accessioned2022-06-08T06:57:39Z
dc.date.available2022-06-08T06:57:39Z
dc.date.issued2022-03-09
dc.identifier.citationNieto-Ruiz A... [et al.] (2022) Infant Formula Supplemented With Milk Fat Globule Membrane, Long-Chain Polyunsaturated Fatty Acids, and Synbiotics Is Associated With Neurocognitive Function and Brain Structure of Healthy Children Aged 6 Years: The COGNIS Study. Front. Nutr. 9:820224. doi: [10.3389/fnut.2022.820224]es_ES
dc.identifier.urihttp://hdl.handle.net/10481/75323
dc.descriptionThis project has been funded by Laboratorios Ordesa, S.L. Contract University of Granada General Foundation, No. 3349 and SMARTFOODS (CIEN) Contract University of Granada General Foundation, No. 4003, Spanish Ministry of Economy, Industry and Competitiveness. Furthermore, the project has been partially funded by HORIZON 2020 EU DynaHEALTH Project (GA No. 633595).es_ES
dc.description.abstractBackground: Adequate nutrient intake during the first few months of life plays a critical role on brain structure and function development. Objectives: To analyze the long-term effects of an experimental infant formula (EF) on neurocognitive function and brain structure in healthy children aged 6 years compared to those fed with a standard infant formula or breastfed. Methods: The current study involved 108 healthy children aged 6 years and participating in the COGNIS Study. At 0–2 months, infants were randomized to receive up to 18 months of life a standard infant formula (SF) or EF enriched with milk fat globule membrane (MFGM), long-chain polyunsaturated fatty acids (LC-PUFAs) and synbiotics. Furthermore, a reference group of breastfed (BF) infants were also recruited. Children were assessed using neurocognitive tests and structural Magnetic Resonance Imaging (MRI) at 6 years old. Results: Experimental infant formula (EF) children showed greater volumes in the left orbital cortex, higher vocabulary scores and IQ, and better performance in an attention task than BF children. EF children also presented greater volumes in parietal regions than SF kids. Additionally, greater cortical thickness in the insular, parietal, and temporal areas were found in children from the EF group than those fed with SF or BF groups. Further correlation analyses suggest that higher volumes and cortical thickness of different parietal and frontal regions are associated with better cognitive development in terms of language (verbal comprehension) and executive function (working memory). Finally, arachidonic acid (ARA), adrenic acid (AdA), docosahexaenoic acid (DHA) levels in cheek cell glycerophospholipids, ARA/DHA ratio, and protein, fatty acid, and mineral intake during the first 18 months of life seem to be associated with changes in the brain structures at 6 years old. Conclusions: Supplemented infant formula with MFGM components, LC-PUFAs, and synbiotics seems to be associated to long-term effects on neurocognitive development and brain structure in children at 6 years old.es_ES
dc.description.sponsorshipLaboratorios Ordesaes_ES
dc.description.sponsorshipContract University of Granada General Foundation 3349es_ES
dc.description.sponsorshipSMARTFOODS (CIEN) Contract University of Granada General Foundation 4003es_ES
dc.description.sponsorshipSpanish Ministry of Economy, Industry and Competitiveness. Furthermorees_ES
dc.description.sponsorshipEU DynaHEALTH Project 633595es_ES
dc.language.isoenges_ES
dc.publisherFrontierses_ES
dc.rightsAtribución 3.0 España*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es/*
dc.subjectNeuroimaginges_ES
dc.subjectEarly nutritiones_ES
dc.subjectInfant formulaes_ES
dc.subjectBreastfeeding es_ES
dc.subjectMFGMes_ES
dc.subjectLC-PUFAses_ES
dc.subjectSynbioticses_ES
dc.subjectCognitiones_ES
dc.titleInfant Formula Supplemented With Milk Fat Globule Membrane, Long-Chain Polyunsaturated Fatty Acids, and Synbiotics Is Associated With Neurocognitive Function and Brain Structure of Healthy Children Aged 6 Years: The COGNIS Studyes_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/H2020/633595es_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES
dc.identifier.doi10.3389/fnut.2022.820224
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersiones_ES


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Atribución 3.0 España
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