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References Values of Soluble alpha-Klotho Serum Levels Using an Enzyme-Linked Immunosorbent Assay in Healthy Adults Aged 18-85 Years
dc.contributor.author | Espuch Oliver, Andrea | |
dc.contributor.author | Vázquez Lorente, Héctor | |
dc.contributor.author | Jurado Fasoli, Lucas | |
dc.contributor.author | Haro Muñoz, Tomás de | |
dc.contributor.author | Díaz Alberola, Irene | |
dc.contributor.author | López Vélez, María del Señor | |
dc.contributor.author | De Haro Romero, Teresa | |
dc.contributor.author | Castillo Garzón, Manuel | |
dc.contributor.author | Amaro Gahete, Francisco José | |
dc.date.accessioned | 2022-06-02T06:13:59Z | |
dc.date.available | 2022-06-02T06:13:59Z | |
dc.date.issued | 2022-04-25 | |
dc.identifier.citation | Espuch-Oliver, A... [et al.]. References Values of Soluble alpha-Klotho Serum Levels Using an Enzyme-Linked Immunosorbent Assay in Healthy Adults Aged 18–85 Years. J. Clin. Med. 2022, 11, 2415. [https://doi.org/10.3390/jcm11092415] | es_ES |
dc.identifier.uri | http://hdl.handle.net/10481/75178 | |
dc.description | Hector Vazquez-Lorente (FPU18/03655) and Lucas Jurado-Fasoli (FPU19/01609) are under an FPU fellowship from the Spanish Ministry of Education. This study is part of a Ph.D. thesis conducted in the Biomedicine Doctoral Studies of the University of Granada, Spain. The APC was funded by San Cecilio University Hospital, FIBAO, IBS-Granada, Spain. | es_ES |
dc.description.abstract | alpha-Klotho protein is a powerful predictor of the aging process and lifespan. Although lowered circulating soluble alpha-Klotho levels have been observed in aged non-healthy individuals, no specific reference values across a wide range of ages and sex using an enzyme-linked immunosorbent assay (ELISA) are available for larger cohorts of healthy individuals. The present analytical cross-sectional study was aimed to establish the reference values of soluble alpha-Klotho serum levels in healthy adults by age and sex groups. A total of 346 (59% women) healthy individuals aged from 18 to 85 years were recruited. Subjects were divided by sex and age as: (i) young (18-34.9 years), (ii) middle-aged (35-54.9 years), and (iii) senior (55-85 years) individuals. The soluble alpha-Klotho levels were measured in serum using ELISA. Senior adults were the age-group that presented the lowest soluble alpha-Klotho serum levels (p < 0.01), with age showing a negative association with soluble alpha-Klotho serum levels (p < 0.001). No differences between sexes were observed. Therefore, soluble alpha-Klotho levels were especially decreased-regardless of sex-in our cohort of healthy individuals because of the physiological decline derived from the aging process. We recommend routine assessments of soluble alpha-Klotho levels using ELISA as a simple and cheap detectable marker of aging that improves quality of life in the elderly. | es_ES |
dc.description.sponsorship | Spanish Government FPU18/03655 FPU19/01609 | es_ES |
dc.description.sponsorship | San Cecilio University Hospital, FIBAO, IBS-Granada, Spain | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | MDPI | es_ES |
dc.rights | Atribución 3.0 España | * |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
dc.subject | alpha-Klotho protein | es_ES |
dc.subject | Aging | es_ES |
dc.subject | ELISA | es_ES |
dc.subject | References values | es_ES |
dc.title | References Values of Soluble alpha-Klotho Serum Levels Using an Enzyme-Linked Immunosorbent Assay in Healthy Adults Aged 18-85 Years | es_ES |
dc.type | journal article | es_ES |
dc.rights.accessRights | open access | es_ES |
dc.identifier.doi | 10.3390/jcm11092415 | |
dc.type.hasVersion | VoR | es_ES |