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dc.contributor.authorReal, Francisca M.
dc.contributor.authorLao Pérez, Miguel 
dc.contributor.authorBurgos Poyatos, Miguel 
dc.contributor.authorJiménez Medina, Rafael 
dc.contributor.authorBarrionuevo Jiménez, Francisco Javier 
dc.date.accessioned2022-05-25T08:26:48Z
dc.date.available2022-05-25T08:26:48Z
dc.date.issued2022-05-10
dc.identifier.citationReal, F. M... [et al.] (2022). Cell adhesion and immune response, two main functions altered in the transcriptome of seasonally regressed testes of two mammalian species. Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, 1– 14. [https://doi.org/10.1002/jez.b.23142]es_ES
dc.identifier.urihttp://hdl.handle.net/10481/74983
dc.descriptionThe authors thank Dr. Slivana Guioli for kindly providing us with the DMRT1 antibody used in this study. This study was funded by the following sources: Spanish Secretaria de Estado de Investigacion, Desarrollo e Innovacion, Ministerio de Econimia y Competitividad (grant number CGL-2015-67108-P), Junta de Andalucia (grant number BIO109), Deutsche Forschungsgemeinschaft (grant numbers MU 880/15-1 and MU 880/27-1), and Helmholtz ERC Recognition Award grant from the Helmholtz-Gemeinschaft (ERC-RA-0033).es_ES
dc.description.abstractIn species with seasonal breeding, male specimens undergo substantial testicular regression during the nonbreeding period of the year. However, the molecular mechanisms that control this biological process are largely unknown. Here, we report a transcriptomic analysis on the Iberian mole, Talpa occidentalis, in which the desquamation of live, nonapoptotic germ cells is the major cellular event responsible for testis regression. By comparing testes at different reproductive states (active, regressing, and inactive), we demonstrate that the molecular pathways controlling the cell adhesion function in the seminiferous epithelium, such as the MAPK, ERK, and TGF‐β signaling, are altered during the regression process. In addition, inactive testes display a global upregulation of genes associated with immune response, indicating a selective loss of the “immune privilege” that normally operates in sexually active testes. Interspecies comparative analyses using analogous data from the Mediterranean pine vole, a rodent species where testis regression is controlled by halting meiosis entry, revealed a common gene expression signature in the regressed testes of these two evolutionary distant species. Our study advances in the knowledge of the molecular mechanisms associated to gonadal seasonal breeding, highlighting the existence of a conserved transcriptional program of testis involution across mammalian clades.es_ES
dc.description.sponsorshipSpanish Secretaria de Estado de Investigacion, Desarrollo e Innovacion, Ministerio de Econimia y Competitividad CGL-2015-67108-Pes_ES
dc.description.sponsorshipJunta de Andalucia BIO109es_ES
dc.description.sponsorshipGerman Research Foundation (DFG) MU 880/15-1 MU 880/27-1es_ES
dc.description.sponsorshipHelmholtz ERC Recognition Award Helmholtz Association ERC-RA-0033es_ES
dc.language.isoenges_ES
dc.publisherWileyes_ES
dc.rightsAtribución 3.0 España*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es/*
dc.subjectCell adhesiones_ES
dc.subjectImmune responsees_ES
dc.subjectMicrotus duodecimcostatuses_ES
dc.subjectSeasonal reproductiones_ES
dc.subjectSeasonal testis regressiones_ES
dc.subjectTalpa occidentalises_ES
dc.subjectTestis transcriptomees_ES
dc.titleCell adhesion and immune response, two main functions altered in the transcriptome of seasonally regressed testes of two mammalian specieses_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES
dc.identifier.doi10.1002/jez.b.23142
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersiones_ES


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Atribución 3.0 España
Except where otherwise noted, this item's license is described as Atribución 3.0 España