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Exploring Short and Efficient Synthetic Routes Using Titanocene(III)-Catalyzed Reactions: Total Synthesis of Natural Meroterpenes with Trisubstituted Unsaturations
dc.contributor.author | Rosales, Jennifer | |
dc.contributor.author | Justicia Ladrón De Guevara, José | |
dc.date.accessioned | 2022-05-10T10:47:52Z | |
dc.date.available | 2022-05-10T10:47:52Z | |
dc.date.issued | 2022-04-08 | |
dc.identifier.citation | Rosales, J.; Cabrera, G.; Justicia, J. Exploring Short and Efficient Synthetic Routes Using Titanocene(III)-Catalyzed Reactions: Total Synthesis of Natural Meroterpenes with Trisubstituted Unsaturations. Molecules 2022, 27, 2400. [https://doi.org/10.3390/molecules27082400] | es_ES |
dc.identifier.uri | http://hdl.handle.net/10481/74785 | |
dc.description | This research was funded by FEDER (EDRF)/Junta de Andalucia-Consejeria de Transformacion Economica, Industria, Conocimiento y Universidades (P18-FR-2877), grant number A-FQM-079-UGR18. | es_ES |
dc.description.abstract | The stereo- and regioselective total syntheses of OMe derivatives of the scarce bioactive meroterpenoids makassaric acid (1) and fascioquinol B (2) have been accomplished. The synthetic sequences are based on the following three efficient and selective catalytic reactions: Cu-catalyzed addition of Grignard compounds to an epoxide; a regioselective Barbier-type reaction, catalyzed by Cp2TiCl; and regio- and stereoselective bioinspired cyclization, also catalyzed by Cp2TiCl. These three key processes allow us to obtain the main skeletons of 1 and 2 in a few steps. The valuable synthetic proposal shown in this work provides fast access to scarce, structurally complex meroterpenes with promising biological activities, which are a sustainable source for later studies and applications in medicine. | es_ES |
dc.description.sponsorship | FEDER (EDRF)/Junta de Andalucia-Consejeria de Transformacion Economica, Industria, Conocimiento y Universidades P18-FR-2877 A-FQM-079-UGR18 | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | MDPI | es_ES |
dc.rights | Atribución 3.0 España | * |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
dc.subject | Terpenes | es_ES |
dc.subject | Natural product | es_ES |
dc.subject | Titanocene | es_ES |
dc.subject | Synthetic methods | es_ES |
dc.subject | Radicals | es_ES |
dc.title | Exploring Short and Efficient Synthetic Routes Using Titanocene(III)-Catalyzed Reactions: Total Synthesis of Natural Meroterpenes with Trisubstituted Unsaturations | es_ES |
dc.type | journal article | es_ES |
dc.rights.accessRights | open access | es_ES |
dc.identifier.doi | 10.3390/molecules27082400 | |
dc.type.hasVersion | VoR | es_ES |