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dc.contributor.authorVargas, E.
dc.contributor.authorAltmae, Signe 
dc.date.accessioned2022-05-10T07:03:57Z
dc.date.available2022-05-10T07:03:57Z
dc.date.issued2022-04-04
dc.identifier.citationE Vargas... [et al.]. The mid-secretory endometrial transcriptomic landscape in endometriosis: a meta-analysis, Human Reproduction Open, Volume 2022, Issue 2, 2022, hoac016, [https://doi.org/10.1093/hropen/hoac016]es_ES
dc.identifier.urihttp://hdl.handle.net/10481/74767
dc.descriptionThis work was supported by the Spanish Ministry of Education, Culture and Sport [grant FPU15/01193] and the Margarita Salas program for the Requalification of the Spanish University system [grant UJAR01MS]; Spanish Ministry of Economy, Industry and Competitiveness (MINECO) and European Regional Development Fund (FEDER): grants RYC-2016-21199 and ENDORE SAF201787526-R; Programa Operativo FEDER Andalucia (B-CTS-500-UGR18; A-CTS-614-UGR20); the Junta de Andalucia [BIO-302; and PAIDI P20_00158]; the University of Jaen [PAIUJA-EI_CTS02_2017]; the University of Granada, Plan Propio de Investigacion 2016, Excellence actions: Units of Excellence; Unit of Excellence on Exercise and Health (UCEES), and by the Junta de Andalucia, Consejeria de Conocimiento, Investigacio n y Universidades and European Regional Development Fund (ERDF), ref. SOMM17/6107/UGR; the Estonian Research Council (grant PRG1076); Horizon 2020 innovation (ERIN, grant no. EU952516) of the European Commission and Enterprise Estonia (grant EU48695).es_ES
dc.description.abstractSTUDY QUESTION: Do women with endometriosis have a different endometrial gene expression profile at the time of embryo implantation than women without endometriosis? SUMMARY ANSWER: The endometrial gene expression profile of women with endometriosis differs from that of women without endometriosis at the mid-secretory phase, although the differences are small. WHAT IS KNOWN ALREADY: About 50% of women with endometriosis suffer infertility. Several molecular studies have suggested impaired endometrial receptivity in women with endometriosis, while others have detected no dysregulation of endometrial receptivity. Nevertheless, the previous endometrial transcriptome studies comparing women with and without endometriosis have been performed in small sample size with limited statistical power. We set out to systematically search and compile data of endometrial gene expression signatures at the receptive phase in women with endometriosis versus control women. Based on the obtained data, we conducted a meta-analysis of differentially expressed genes in order to raise the power of the analysis for identifying the molecular profiles of receptive phase endometria in endometriosis. STUDY DESIGN, SIZE, DURATION: A systematic literature search was conducted up to February 2022 following PRISMA criteria and included PubMed, Cochrane and Web of Science databases. For the systematic search, the term ‘endometriosis’ was paired with the terms ‘transcriptomics’, ‘transcriptome’, ‘gene expression’, ‘RNA-seq’, ‘sequencing’ and ‘array’, by using the Boolean operator ‘AND’ to connect them. Articles written in English were screened and interrogated for data extraction. PARTICIPANTS/MATERIALS, SETTING, METHODS: A meta-analysis was performed on the selected studies to extract the differentially expressed genes described at the mid-secretory phase in women with endometriosis versus women without endometriosis in natural cycles, using the robust rank aggregation method. In total, transcriptome data of 125 women (78 patients and 47 controls) were metaanalysed, with a special focus on endometrial receptivity-specific genes based on commercial endometrial receptivity tests. MAIN RESULTS AND THE ROLE OF CHANCE: In total, 8 studies were eligible for the quantitative meta-analysis, gathering transcriptome data from the mid-secretory phase endometria of 125 women. A total of 7779 differentially expressed transcripts between the study groups were retrieved (3496 up-regulated and 4283 down-regulated) and were meta-analysed. After stringent multiple correction, there was no differential expression of any single molecule in the endometrium of women with endometriosis versus controls, while enrichment analysis detected that the pathways of chemotaxis and locomotion are dysregulated in endometriosis. Further analysis of endometrial receptivity-specific genes highlighted dysregulation of C4BPA, MAOA and PAEP and enrichment of immune and defence pathways in women with endometriosis. LIMITATIONS, REASONS FOR CAUTION: Most of the studies included into the meta-analysis were relatively small and had different study designs, which might have contributed to a bias. WIDER IMPLICATIONS OF THE FINDINGS: The current meta-analysis supports the hypothesis that endometrial receptivity is altered in women with endometriosis, although the changes are small. The molecules and pathways identified could serve as future biomarkers and therapeutical targets in detecting and treating endometriosis-associated infertility.es_ES
dc.description.sponsorshipSpanish Government FPU15/01193es_ES
dc.description.sponsorshipEuropean Commission RYC-2016-21199 ENDORE SAF201787526-Res_ES
dc.description.sponsorshipPrograma Operativo FEDER Andalucia B-CTS-500-UGR18 A-CTS-614-UGR20es_ES
dc.description.sponsorshipJunta de Andalucia BIO-302 PAIDI P20_00158es_ES
dc.description.sponsorshipUniversity of Jaen PAIUJA-EI_CTS02_2017es_ES
dc.description.sponsorshipUniversity of Granada, Plan Propio de Investigacion 2016, Excellence actions: Units of Excellence; Unit of Excellence on Exercise and Health (UCEES)es_ES
dc.description.sponsorshipJunta de Andaluciaes_ES
dc.description.sponsorshipEuropean Commission SOMM17/6107/UGRes_ES
dc.description.sponsorshipEstonian Research Council PRG1076es_ES
dc.description.sponsorshipHorizon 2020 innovation (ERIN) of the European Commission EU952516es_ES
dc.description.sponsorshipEnterprise Estonia EU48695es_ES
dc.description.sponsorshipMargarita Salas program for the Requalification of the Spanish University system UJAR01MSes_ES
dc.language.isoenges_ES
dc.publisherOxford University Presses_ES
dc.rightsAtribución-NoComercial 3.0 España*
dc.rights.urihttp://creativecommons.org/licenses/by-nc/3.0/es/*
dc.subjectEndometriosises_ES
dc.subjectEndometriumes_ES
dc.subjectInfertility es_ES
dc.subjectMeta-analysises_ES
dc.subjectTranscriptomicses_ES
dc.titleThe mid-secretory endometrial transcriptomic landscape in endometriosis: a meta-analysises_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/H2020/952516es_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES
dc.identifier.doi10.1093/hropen/hoac016
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersiones_ES


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