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Hyaluronic acid and human/bovine serum albumin shelled nanocapsules: Interaction with mucins and in vitro digestibility of interfacial films
dc.contributor.author | Castillo Santaella, Teresa del | |
dc.contributor.author | Aguilera Garrido, Aixa María | |
dc.contributor.author | Galisteo González, Francisco | |
dc.contributor.author | Gálvez Ruiz, María José | |
dc.contributor.author | Molina Bolívar, José Antonio | |
dc.contributor.author | Maldonado Valderrama, Julia | |
dc.date.accessioned | 2022-05-06T12:28:21Z | |
dc.date.available | 2022-05-06T12:28:21Z | |
dc.date.issued | 2022-02-03 | |
dc.identifier.citation | Teresa del Castillo-Santaella... [et al.]. Hyaluronic acid and human/bovine serum albumin shelled nanocapsules: Interaction with mucins and in vitro digestibility of interfacial films, Food Chemistry, Volume 383, 2022, 132330, ISSN 0308-8146, [https://doi.org/10.1016/j.foodchem.2022.132330] | es_ES |
dc.identifier.uri | http://hdl.handle.net/10481/74735 | |
dc.description | This work has been supported by project RTI2018-101309-B-C21 funded by MCIN/AEI/10.13039/501100011033/FEDER. The authors are also grateful to the "Mancomunidad de los Pueblos de la Alpujarra Granadina" for the funds raised and supplied for this research by "Solidaridad entre montanas" project. This work was also partially supported by the Biocolloid and Fluid Physics Group (ref. PAI-FQM115) of the University of Granada (Spain). JMV acknowledges support from project Project PID2020-116615RA-I00 funded by MCIN/AEI/10.13039/501100011033. This work has been done in the framework of the doctorate of AAG in the Doctoral Programme in Biomedicine (B11/56/1) of the University of Granada. Funding for open access charge: Universidad de Granada/CBUA. | es_ES |
dc.description.abstract | Liquid lipid nanocapsules are oil droplets surrounded by a protective shell, which enable high load and allow controlled delivery of lipophilic compounds. However, their use in food formulations requires analysing their digestibility and interaction with mucin. Here, serum albumins and hyaluronic acid shelled olive oil nanocapsules are analysed to discern differences between human and bovine variants, the latter usually used as model system. Interfacial interaction of albumins and hyaluronic acid reveals that human albumin presents limited conformational changes upon adsorption, which increase by complexation with the polysaccharide present at the interface. The latter also promotes hydrophobic interactions with mucin, especially at pH 3 and protects albumin interfacial layer under in vitro gastric digestion. The interfacial unfolding induced in human albumin by hyaluronic acid facilitates in vitro lipolysis while its limited conformational changes provide the largest protection against in vitro lipolysis. | es_ES |
dc.description.sponsorship | Mancomunidad de los Pueblos de la Alpujarra Granadina | es_ES |
dc.description.sponsorship | Biocolloid and Fluid Physics Group of the University of Granada (Spain) PAI-FQM115 | es_ES |
dc.description.sponsorship | University of Granada B11/56/1 Universidad de Granada/CBUA RTI2018-101309-B-C21 MCIN/AEI/10.13039/501100011033/FEDER PID2020-116615RA-I00 MCIN/AEI/10.13039/501100011033 | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Elsevier | es_ES |
dc.rights | Atribución 3.0 España | * |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
dc.subject | Albumin | es_ES |
dc.subject | Hyaluronic acid | es_ES |
dc.subject | Digestion | es_ES |
dc.subject | Mucin | es_ES |
dc.subject | Emulsion | es_ES |
dc.subject | Interfacial tension | es_ES |
dc.title | Hyaluronic acid and human/bovine serum albumin shelled nanocapsules: Interaction with mucins and in vitro digestibility of interfacial films | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es_ES |
dc.identifier.doi | 10.1016/j.foodchem.2022.132330 | |
dc.type.hasVersion | info:eu-repo/semantics/publishedVersion | es_ES |