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dc.contributor.authorBarranco Pérez, Alejandro 
dc.contributor.authorGarcía, Llenalia
dc.contributor.authorRueda, Ricardo
dc.contributor.authorRamírez, María
dc.date.accessioned2022-04-25T11:42:28Z
dc.date.available2022-04-25T11:42:28Z
dc.date.issued2022-03-05
dc.identifier.citationBarranco, A... [et al.]. Effects of -Hydroxy -Methylbutyrate Supplementation on Working Memory and Hippocampal Long-Term Potentiation in Rodents. Nutrients 2022, 14, 1090. [https://doi.org/10.3390/nu14051090]es_ES
dc.identifier.urihttp://hdl.handle.net/10481/74533
dc.description.abstractbeta-hydroxy beta-methylbutyrate (HMB), a metabolite of the essential amino acid leucine, has been shown to preserve muscle mass and strength during aging. The signaling mechanism by which HMB elicits its favorable effects on protein metabolism in skeletal muscle is also preserved in the brain. However, there are only a few studies, all at relatively high doses, addressing the effect of HMB supplementation on cognition. This study evaluated the effects of different doses of HMB on the potentiation of hippocampal synapses following the experimental induction of long-term potentiation (LTP) in the hippocampus of behaving rats, as well as on working memory test (delayed matching-to-position, DMTP) in mice. HMB doses in rats were 225 (low), 450 (medium), and 900 (high) mg/kg body weight/day and were double in mice. Rats who received medium or high HMB doses improved LTP, suggesting that HMB administration enhances mechanisms related to neuronal plasticity. In the DMTP test, mice that received any of the tested doses of HMB performed better than the control group in the overall test with particularities depending on the dose and the task phase.es_ES
dc.language.isoenges_ES
dc.publisherMDPIes_ES
dc.rightsAtribución 3.0 España*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es/*
dc.subjectAging es_ES
dc.subjectNutrition es_ES
dc.subjectbeta-hydroxy beta-methylbutyratees_ES
dc.subjectDelayed matching-to-positiones_ES
dc.subjectLong-term potentiationes_ES
dc.subjectCognitiones_ES
dc.subjectIntelliCages®es_ES
dc.titleEffects of beta-Hydroxy beta-Methylbutyrate Supplementation on Working Memory and Hippocampal Long-Term Potentiation in Rodentses_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES
dc.identifier.doi10.3390/nu14051090
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersiones_ES


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