Asymmetric Interaction of Neuropeptidase Activities between Cortico-Limbic Structures, Plasma and Cardiovascular Function after Unilateral Dopamine Depletions of the Nigrostriatal System
Metadatos
Afficher la notice complèteAuteur
Banegas, Inmaculada; Vives Montero, Francisco; Durán Ogalla, Raquel; Luna Del Castillo, Juan De Dios; Domínguez Vías, GermanEditorial
MDPI
Materia
Neuropeptides Neuropeptidases Neurochemical asymmetry Functional asymmetry Neurovisceral integration
Date
2022-01-29Referencia bibliográfica
Banegas, I... [et al.]. Asymmetric Interaction of Neuropeptidase Activities between Cortico-Limbic Structures, Plasma and Cardiovascular Function after Unilateral Dopamine Depletions of the Nigrostriatal System. Biomedicines 2022, 10, 326. [https://doi.org/10.3390/biomedicines10020326]
Patrocinador
Junta de Andalucia PAI CVI-221 CTS 438Résumé
In emotional processing, dopamine (DA) plays an essential role, and its deterioration
involves important consequences. Under physiological conditions, dopamine exhibits brain asymmetry
and coexists with various neuropeptides that can coordinate the processing of brain functions.
Brain asymmetry can extend into a broader concept of asymmetric neurovisceral integration, including
behavior. The study of the activity of neuropeptide regulatory enzymes (neuropeptidases,
NPs) is illustrative. We have observed that the left and right brain areas interact intra- and interhemispherically,
as well as with peripheral tissues or with physiological parameters such as blood
pressure or with behaviors such as turning preference. To obtain data that reflect this integrative
behavior, we simultaneously analyzed the impact of left or right brain DA depletion on the activity of
various NPs in corticolimbic regions of the left and right hemispheres, such as the medial prefrontal
cortex, amygdala and hippocampus, as well as on the plasma activity of the same aminopeptidase
activities (APs) and on systolic blood pressure (SBP). Intra- and inter-hemispheric interactions as well
as the interactions of NPs from the left or right hemispheres were analyzed with the same plasma
APs and the SBP obtained from sham and from left or right lesioned rats. The results demonstrate a
complex profile depending on the hemisphere considered. They definitively confirm an asymmetric
neurovisceral integration and reveal a higher level of inter-hemispheric corticolimbic interactions
including with SBP after left dopamine depletion.