Zn-containing Adhesives Facilitate Collagen Protection and Remineralization at the Resin-Dentin Interface: A Narrative Review
Metadatos
Mostrar el registro completo del ítemAutor
Toledano Pérez, Manuel; Toledano Osorio, Manuel; Carrasco Carmona, Álvaro; Toledano Osorio, María; Osorio Ruiz, RaquelEditorial
MDPI
Materia
Zinc Adhesive Polymers Dentin Remineralization Degradation Interface
Fecha
2022-02-08Referencia bibliográfica
Toledano, M... [et al.]. Zn-containing Adhesives Facilitate Collagen Protection and Remineralization at the Resin-Dentin Interface: A Narrative Review. Polymers 2022, 14, 642. [https://doi.org/10.3390/polym14030642]
Patrocinador
Ministry of Economy and Competitiveness; European Commission PID2020-114694RB-100 MINECO/AEI/FEDER/UE; Ministry of Universities FPU20/00450Resumen
This is a narrative review of the literature assessing the potential effectiveness of doping
dentin polymeric adhesives with zinc compounds in order to improve bonding efficacy, remineralization
and protection against degradation. A literature search was conducted using electronic
databases, such as PubMed, MEDLINE, DIMDI andWeb of Science. Through our search, we found
literature demonstrating that Zn-doped dentin adhesives promote protection and remineralization of
the resin-dentin interfaces. The increased bioactivity has also facilitated dentinal tubules’ occlusion
by crystals’ precipitation contributing to improved sealing efficacy of restorations. Loading dentin
adhesives with zinc gives rise to an increase of both crystallinity of mineral and crosslinking of
collagen. The main role of zinc, in dentin adhesives, is to inhibit collagen proteolysis. We concluded
that zinc exerts a protective effect through binding at the collagen-sensitive cleavage sites of matrixmetalloproteinases
(MMPs), contributing to dentin matrix stabilization. Zinc may not only act as
a MMPs inhibitor, but also influence signaling pathways and stimulate metabolic effects in dentin
mineralization and remineralization processes. Zn-doped adhesives increase the longevity of dentin
bonding through MMPs inhibition. Zn poses a remineralization strategy in demineralized dentin.