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Progressive Multifocal Leukoencephalopathy and Immune Reconstitution Inflammatory Syndrome after Discontinuation of Fingolimod

dc.contributor.authorPiñar Morales, Raquel 
dc.contributor.authorCarrasco Garcia, María
dc.contributor.authorGutiérrez Rojas, Luis 
dc.contributor.authorBarrero Hernández, Francisco Javier 
dc.date.accessioned2022-03-02T12:14:48Z
dc.date.available2022-03-02T12:14:48Z
dc.date.issued2022-02-07
dc.identifier.citationMorales, R. P., Garcia, M. C., Gutierrez-Rojas, L., & Hernández, F. J. B. (2022). Progressive Multifocal Leukoencephalopathy and Immune Reconstitution Inflammatory Syndrome after Discontinuation of Fingolimod. Case Reports in Neurology, 14, 38-43. [https://doi.org/10.1159/000521944]es_ES
dc.identifier.urihttp://hdl.handle.net/10481/73069
dc.descriptionR.P.M. and F.J.B.H. have contributed to the conception and design of the work. R.P.M. and M.C.G. have contributed to the acquisition, analysis, and interpretation of data for the work. L.G.R. and F.J.B.H. have contributed to drafting the work and revising it critically. All the authors have approved the version to be published.es_ES
dc.description.abstractProgressive multifocal leukoencephalopathy (PML) is a rare complication of immunosuppressive treatment in MS patients. Immune reconstitution inflammatory syndrome (IRIS) appears after the withdrawal of certain drugs such as natalizumab (NTZ) or fingolimod. The development of PML-IRIS after NTZ treatment has been described, and its diagnosis is made by clinical and radiological criteria and the determination of the John Cunningham virus in CSF. We present a clinical case of a patient with MS who, after the withdrawal of fingolimod, developed PML-IRIS despite sustained lymphopenia. This is important for pharmacovigilance purposes, not only for NTZ but also for alternative drugs used in MS treatment.es_ES
dc.language.isoenges_ES
dc.publisherS. Karger AGes_ES
dc.rightsAtribución-NoComercial 3.0 España*
dc.rights.urihttp://creativecommons.org/licenses/by-nc/3.0/es/*
dc.subjectFingolimodes_ES
dc.subjectImmune reconstitution inflammatory syndromees_ES
dc.subjectMagnetic resonance imaging es_ES
dc.subjectMultiple sclerosis es_ES
dc.subjectProgressive multifocal leukoencephalopathyes_ES
dc.titleProgressive Multifocal Leukoencephalopathy and Immune Reconstitution Inflammatory Syndrome after Discontinuation of Fingolimodes_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES
dc.identifier.doi10.1159/000521944
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersiones_ES


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