MirGeneDB 2.1: toward a complete sampling of all major animal phyla
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Show full item recordEditorial
Oxford University Press
Date
2021-11-25Referencia bibliográfica
Bastian Fromm... [et al.]. MirGeneDB 2.1: toward a complete sampling of all major animal phyla, Nucleic Acids Research, Volume 50, Issue D1, 7 January 2022, Pages D204–D210, [https://doi.org/10.1093/nar/gkab1101]
Sponsorship
Tromso forskningsstiftelse (TFS) 20_SG_BF; Strategic Research Area (SFO) program of the Swedish Research Council through Stockholm University; European Research Council (ERC) European Commission 758397; South-Eastern Norway Regional Health Authority 2018014; Junior Scholars Program (Dartmouth College); School of Life Sciences University of Nottingham; Spanish Government; European Commission AGL2017-88702-C2-2-R; University of Granada A-BIO-481-UGR18 FEDER 18; National Science Foundation (NSF); National Aeronautics & Space Administration (NASA); Dartmouth CollegeAbstract
We describe an update of MirGeneDB, the manually
curated microRNA gene database. Adhering to
uniform and consistent criteria for microRNA
annotation and nomenclature, we substantially
expanded MirGeneDB with 30 additional species
representing previously missing metazoan phyla
such as sponges, jellyfish, rotifers and flatworms.
MirGeneDB 2.1 now consists of 75 species spanning
over ∼800 million years of animal evolution, and
contains a total number of 16 670 microRNAs from
1549 families. Over 6000 microRNAs were added in
this update using ∼550 datasets with ∼7.5 billion
sequencing reads. By adding new phylogenetically
important species, especially those relevant for
the study of whole genome duplication events,
and through updating evolutionary nodes of origin
for many families and genes, we were able to
substantially refine our nomenclature system. All changes are traceable in the specifically developed
MirGeneDB version tracker. The performance of
read-pages is improved and microRNA expression
matrices for all tissues and species are now also
downloadable. Altogether, this update represents
a significant step toward a complete sampling of
all major metazoan phyla, and a widely needed
foundation for comparative microRNA genomics and
transcriptomics studies. MirGeneDB 2.1 is part of
RNAcentral and Elixir Norway, publicly and freely
available at http://www.mirgenedb.org/.