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dc.contributor.authorMullins, Niamh
dc.contributor.authorCervilla Ballesteros, Jorge Antonio 
dc.contributor.authorGutiérrez Martínez, Blanca 
dc.contributor.authorMolina Rivas, Esther 
dc.contributor.authorRivera Sánchez, Margarita 
dc.contributor.authorPsychiat Genomics Consortium
dc.contributor.authorGerman Borderline Genomics Consort
dc.contributor.authorMVP Suicide Exemplar Workgrp
dc.contributor.authorVA Million Vet Program
dc.date.accessioned2022-02-11T11:31:02Z
dc.date.available2022-02-11T11:31:02Z
dc.date.issued2021-09-09
dc.identifier.citationMullins, N... [et al.]. Dissecting the Shared Genetic Architecture of Suicide Attempt, Psychiatric Disorders, and Known Risk Factors, Biological Psychiatry, Volume 91, Issue 3, 2022, Pages 313-327, ISSN 0006-3223, [https://doi.org/10.1016/j.biopsych.2021.05.029]es_ES
dc.identifier.urihttp://hdl.handle.net/10481/72795
dc.descriptionStatistical analyses were carried out on the NL Genetic Cluster Computer (http://www.geneticcluster.org) hosted by SURFsara and the Mount Sinai high performance computing cluster (http://hpc.mssm.edu), which is supported by the Office of Research Infrastructure of the National Institutes of Health (Grant Nos. S10OD018522 and S10OD026880). This work was conducted in part using the resources of the Advanced Computing Center for Research and Education at Vanderbilt University, Nashville, TN. This work was funded by the National Institutes of Health (Grant Nos. R01MH116269 and R01MH121455 [to DMR]), NIGMS of the National Institutes of Health (Grant No. T32GM007347 [to JK]), and the Brain & Behavior Research Foundation (NARSAD Young Investigator Award No. 29551 [to NM]).es_ES
dc.description.abstractBACKGROUND: Suicide is a leading cause of death worldwide, and nonfatal suicide attempts, which occur far more frequently, are a major source of disability and social and economic burden. Both have substantial genetic etiology, which is partially shared and partially distinct from that of related psychiatric disorders. METHODS: We conducted a genome-wide association study (GWAS) of 29,782 suicide attempt (SA) cases and 519,961 controls in the International Suicide Genetics Consortium (ISGC). The GWAS of SA was conditioned on psychiatric disorders using GWAS summary statistics via multitrait-based conditional and joint analysis, to remove genetic effects on SA mediated by psychiatric disorders. We investigated the shared and divergent genetic architectures of SA, psychiatric disorders, and other known risk factors. RESULTS: Two loci reached genome-wide significance for SA: the major histocompatibility complex and an intergenic locus on chromosome 7, the latter of which remained associated with SA after conditioning on psychiatric disorders and replicated in an independent cohort from the Million Veteran Program. This locus has been implicated in risk-taking behavior, smoking, and insomnia. SA showed strong genetic correlation with psychiatric disorders, particularly major depression, and also with smoking, pain, risk-taking behavior, sleep disturbances, lower educational attainment, reproductive traits, lower socioeconomic status, and poorer general health. After conditioning on psychiatric disorders, the genetic correlations between SA and psychiatric disorders decreased, whereas those with nonpsychiatric traits remained largely unchanged. CONCLUSIONS: Our results identify a risk locus that contributes more strongly to SA than other phenotypes and suggest a shared underlying biology between SA and known risk factors that is not mediated by psychiatric disorders.es_ES
dc.description.sponsorshipOffice of Research Infrastructure of the National Institutes of Health S10OD018522 S10OD026880es_ES
dc.description.sponsorshipUnited States Department of Health & Human Serviceses_ES
dc.description.sponsorshipNational Institutes of Health (NIH) - USA R01MH116269 R01MH121455es_ES
dc.description.sponsorshipUnited States Department of Health & Human Serviceses_ES
dc.description.sponsorshipNIH National Institute of General Medical Sciences (NIGMS) T32GM007347 NARSAD 29551es_ES
dc.language.isoenges_ES
dc.publisherElsevieres_ES
dc.rightsAtribución-NoComercial-SinDerivadas 3.0 España*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es/*
dc.titleDissecting the Shared Genetic Architecture of Suicide Attempt, Psychiatric Disorders, and Known Risk Factorses_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES
dc.identifier.doi10.1016/j.biopsych.2021.05.029
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersiones_ES


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