Tissue Engineering and Regeneration of the Human Hair Follicle in Androgenetic Alopecia: Literature Review
Metadatos
Afficher la notice complèteAuteur
Llamas Molina, José María; Carrero Castaño, Alejandro; Ruiz Villaverde, Ricardo; Campos Muñoz, Antonio JesúsEditorial
MDPI
Materia
Hair follicle Androgenetic alopecia Tissue engineering Regenerative medicine Bioengineering
Date
2022-01-14Referencia bibliográfica
Llamas-Molina, J.M... [et al.]. Tissue Engineering and Regeneration of the Human Hair Follicle in Androgenetic Alopecia: Literature Review. Life 2022, 12, 117. [https://doi.org/10.3390/life12010117]
Patrocinador
Instituto de Investigacion Biosanitaria de Granada (Ibs)Résumé
Androgenetic alopecia (AGA) is an androgen-dependent process and represents the most
frequent non-scarring alopecia. Treatments for AGA do not always achieve a satisfactory result
for the patient, and sometimes cause side effects that lead to discontinuation of treatment. AGA
therapeutics currently includes topical and oral drugs, as well as follicular unit micro-transplantation
techniques. Tissue engineering (TE) is postulated as one of the possible future solutions to the
problem and aims to develop fully functional hair follicles that maintain their cyclic rhythm in a
physiological manner. However, despite its great potential, reconstitution of fully functional hair
follicles is still a challenge to overcome and the knowledge gained of the key processes in hair follicle
morphogenesis and biology has not yet been translated into effective replacement therapies in clinical
practice. To achieve this, it is necessary to research and develop new approaches, techniques and
biomaterials. In this review, present and emerging hair follicle bioengineering strategies are evaluated.
The current problems of these bioengineering techniques are discussed, as well as the advantages and
disadvantages, and the future prospects for the field of TE and successful hair follicle regeneration.