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dc.contributor.authorSolís Urra, Patricio 
dc.contributor.authorEsteban Cornejo, Irene 
dc.contributor.authorRodríguez Ayllón, María
dc.contributor.authorVerdejo Román, Juan 
dc.contributor.authorCatena Martínez, Andrés 
dc.contributor.authorOrtega Porcel, Francisco Bartolomé 
dc.date.accessioned2022-02-02T08:13:30Z
dc.date.available2022-02-02T08:13:30Z
dc.date.issued2021-11-15
dc.identifier.citationPatricio Solis-Urra... [et al.]. Early life factors and white matter microstructure in children with overweight and obesity: The ActiveBrains project, Clinical Nutrition, Volume 41, Issue 1, 2022, Pages 40-48, ISSN 0261-5614, [https://doi.org/10.1016/j.clnu.2021.10.022]es_ES
dc.identifier.urihttp://hdl.handle.net/10481/72598
dc.descriptionThis study was supported by the Spanish Ministry of Economy and Competitiveness (DEP2013-47540, DEP2016-79512-R, and DEP2017-91544-EXP), the European Regional Development Fund, the European Commission (No 667302) and the Alicia Koplowitz Foundation. This study was partially funded by the UGR Research and Knowledge Transfer Fund (PPIT) 2016, Excellence Actions Programme. Units of Scientific Excellence; Scientific Unit of Excellence on Exercise and Health (UCEES) and by the Regional Government of Andalusia, Regional Ministry of Economy, Knowledge, Entreprises and University and European Regional Development Fund (ERDF), ref. SOMM17/6107/UGR. In addition, this study was further supported by the SAMID III network, RETICS, funded by the PN IthornDthornI 2017-2021 (Spain). Additional funding was obtained from the Andalusian Operational Programme supported with European Regional Development Funds (ERDF in English, FEDER in Spanish, project ref: B-CTS-355-UGR18). PS-U is supported by a grant from ANID/BECAS Chile/72180543. IE-C is supported by the Spanish Ministries of Economy and Competitiveness (RTI2018-095284-J-100), and Science and Innovation (RYC2019-027287-I). JV-R is supported by a grant from the Spanish Ministry of Science, Innovation and Universities (FJCI-2017-33396). Funding for open access charge: Universidad de Granada/CBUA. We would like to thank all the families participating in the ActiveBrains. We are grateful to Ms. Ana Yara Postigo-Fuentes for her assistance with the English language. We also acknowledge everyone who helped with the data collection and all of the members involved in the fieldwork for their effort, enthusiasm, and support. This work is part of Ph.D. Thesis conducted in the Biomedicine Doctoral Studies of the University of Granada, Spain.es_ES
dc.description.abstractBackground & aims: Exposure to a suboptimal environment during the fetal and early infancy period's results in long-term consequences for brain morphology and function. We investigated the associations of early life factors such as anthropometric neonatal data (i.e., birth length, birth weight and birth head circumference) and breastfeeding practices (i.e., exclusive and any breastfeeding) with white matter (WM) microstructure, and ii) we tested whether WM tracts related to early life factors are associated with academic performance in children with overweight/obesity. Methods: 96 overweight/obese children (10.03 +/- 1.16 years; 38.7% girls) were included from the ActiveBrains Project. WM microstructure indicators used were fractional anisotropy (FA) and mean diffusivity (MD), derived from Diffusion Tensor Imaging. Academic performance was evaluated with the Battery III Woodcock-Munoz Tests of Achievement. Regression models were used to examine the associations of the early life factors with tract-specific FA and MD, as well as its association with academic performance. Results: Head circumference at birth was positively associated with FA of the inferior fronto-occipital fasciculus tract (0.441; p = 0.005), as well as negatively associated with MD of the cingulate gyrus part of cingulum (-0.470; p = 0.006), corticospinal (-0.457; p = 0.005) and superior thalamic radiation tract (-0.476; p = 0.001). Association of birth weight, birth length and exclusive breastfeeding with WM microstructure did not remain significant after false discovery rate correction. None tract related to birth head circumference was associated with academic performance (all p > 0.05). Conclusions: Our results highlighted the importance of the perinatal growth in WM microstructure later in life, although its possible academic implications remain inconclusive.es_ES
dc.description.sponsorshipSpanish Government DEP2013-47540 DEP2016-79512-R DEP2017-91544-EXPes_ES
dc.description.sponsorshipEuropean Commission European Commission European Commission Joint Research Centre 667302es_ES
dc.description.sponsorshipAlicia Koplowitz Foundationes_ES
dc.description.sponsorshipUGR Research and Knowledge Transfer Fund (PPIT) 2016, Excellence Actions Programmees_ES
dc.description.sponsorshipEuropean Commission SOMM17/6107/UGRes_ES
dc.description.sponsorshipSAMID III network, RETICS - PN I+D+I 2017-2021 (Spain)es_ES
dc.description.sponsorshipAndalusian Operational Programme - European Regional Development Funds B-CTS-355-UGR18es_ES
dc.description.sponsorshipANID/BECAS Chile 72180543es_ES
dc.description.sponsorshipSpanish Government RTI2018-095284-J-100 FJCI-2017-33396 RYC2019-027287-Ies_ES
dc.language.isoenges_ES
dc.publisherElsevieres_ES
dc.rightsAtribución 3.0 España*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es/*
dc.subjectChildhoodes_ES
dc.subjectBirth weightes_ES
dc.subjectWhite matteres_ES
dc.subjectAcademic achievement es_ES
dc.titleEarly life factors and white matter microstructure in children with overweight and obesity: The ActiveBrains projectes_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/H2020/667302es_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES
dc.identifier.doi10.1016/j.clnu.2021.10.022
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersiones_ES


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