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dc.contributor.authorViana Pires, Liliane
dc.contributor.authorGonzález Gil, Esther M. 
dc.contributor.authorAnguita Ruiz, Augusto
dc.contributor.authorGil Hernández, Ángel 
dc.contributor.authorLeis, Rosaura
dc.contributor.authorAguilera García, Concepción María 
dc.date.accessioned2022-02-01T09:02:29Z
dc.date.available2022-02-01T09:02:29Z
dc.date.issued2021-12-15
dc.identifier.citationPires, L.V... [et al.]. The Vitamin D Decrease in Children with Obesity Is Associated with the Development of Insulin Resistance during Puberty: The PUBMEP Study. Nutrients 2021, 13, 4488. [https://doi.org/10.3390/nu13124488]es_ES
dc.identifier.urihttp://hdl.handle.net/10481/72579
dc.descriptionThis work was supported by the Plan Nacional de Investigación Científica, Desarrollo e Innovación Tecnológica (I + D + I), Instituto de Salud Carlos III-Health Research Funding (FONDOS FEDER) (PI11/01425, PI11/02042, PI11/02059, PI16/01301, PI16/01205, PI16/00871 and PI20/00563); CIBEROBN Network (CB15/00131, CB15/00043); Redes temáticas de investigación cooperativa RETIC (Red SAMID RD12/0026/0015). The authors also acknowledge Instituto de Salud Carlos III for personal funding: Contratos i-PFIS: doctorados IIS-empresa en ciencias y tecnologías de la salud de la convocatoria 2017 de la Acción Estratégica en Salud 2013–2016 (IFI17/00048). E.M.G.-G. holds a Juan de la Cierva-Formación grant (FJCI-2017-34967) from the Ministerio de Ciencia e Innovación (Spanish Government). L.V.P. acknowledges financial support of the Visiting Professor Program from the Coordination for the Improvement of Higher Education Personnel (CAPES—Grant 88881.337237/2019-01), Brazil.es_ES
dc.description.abstractObesity and cardiometabolic risk have been associated with vitamin D levels even in children. The objective of the present study was to evaluate the association between insulin resistance (IR), cardiometabolic risk factors, and vitamin D in children from prepubertal to pubertal stages. A total of 76 children from the PUBMEP study, aged 4-12 years at baseline, were included. Children were evaluated in prepubertal and pubertal stages. Anthropometric measurements and selected cardiometabolic risk biomarkers, such as plasma glucose, blood lipids, insulin, adiponectin, leptin, and blood pressure, and serum 25-hydroxyvitamin D (25(OH)D) were determined. Children were categorized by obesity degree and IR status combined before and after puberty. Paired t-test and multivariate linear regression analyses were conducted. During puberty, the increase in triacylglycerols, insulin, and HOMA-IR and the decrease in QUICKI were significantly associated with the reduction in 25(OH)D (B = -0.274, p = 0.032; B = -0.219, p = 0.019; B = -0.250, p = 0.013; B = 1.574, p = 0.013, respectively) after adjustment by BMI-z, sex, and pubertal stage. Otherwise, prepubertal non-IR children with overweight/obesity that became IR during puberty showed a significant decrease in 25(OH)D and HDL-c, and an increase in waist circumference and triacylglycerol concentrations (p < 0.05 for all) over time. These results suggest that changes in IR seem to be associated with an effect on 25(OH)D levels during puberty, especially in children with overweight.es_ES
dc.description.sponsorshipPlan Nacional de Investigación Científica, Desarrollo e Innovación Tecnológica (I + D + I)es_ES
dc.description.sponsorshipInstituto de Salud Carlos III-Health Research Funding (FONDOS FEDER) (PI11/01425, PI11/02042, PI11/02059, PI16/01301, PI16/01205, PI16/00871 and PI20/00563)es_ES
dc.description.sponsorshipCIBEROBN Network (CB15/00131, CB15/00043)es_ES
dc.description.sponsorshipRedes temáticas de investigación cooperativa RETIC (Red SAMID RD12/0026/0015)es_ES
dc.description.sponsorshipInstituto de Salud Carlos III (IFI17/00048)es_ES
dc.description.sponsorshipJuan de la Cierva-Formación grant (FJCI-2017-34967) Ministerio de Ciencia e Innovación (Spanish Government)es_ES
dc.description.sponsorshipCoordination for the Improvement of Higher Education Personnel (CAPES—Grant 88881.337237/2019-01), Braziles_ES
dc.language.isoenges_ES
dc.publisherMDPIes_ES
dc.rightsAtribución 3.0 España*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es/*
dc.subjectVitamin D es_ES
dc.subjectCardiometabolic risk factorses_ES
dc.subjectPuberty es_ES
dc.subjectObesity es_ES
dc.subjectInsulin resistancees_ES
dc.subjectChildes_ES
dc.titleThe Vitamin D Decrease in Children with Obesity Is Associated with the Development of Insulin Resistance during Puberty: The PUBMEP Studyes_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES
dc.identifier.doi10.3390/nu13124488
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersiones_ES


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Atribución 3.0 España
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