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Physiological Doses of Hydroxytyrosol Modulate Gene Expression in Skeletal Muscle of Exercised Rats
dc.contributor.author | Casuso Pérez, Rafael Antonio | |
dc.contributor.author | Al Fazazi, Saad | |
dc.contributor.author | Plaza Díaz, Julio | |
dc.contributor.author | Ruiz Ojeda, Francisco Javier | |
dc.contributor.author | Rueda Robles, Ascensión | |
dc.contributor.author | Aragón Vela, Jerónimo | |
dc.contributor.author | Rodríguez Huertas, Jesús Francisco | |
dc.date.accessioned | 2022-01-31T13:24:44Z | |
dc.date.available | 2022-01-31T13:24:44Z | |
dc.date.issued | 2021-12-12 | |
dc.identifier.citation | Casuso, R.A... [et al.]. Physiological Doses of Hydroxytyrosol Modulate Gene Expression in Skeletal Muscle of Exercised Rats. Life 2021, 11, 1393. [https://doi.org/10.3390/life11121393] | es_ES |
dc.identifier.uri | http://hdl.handle.net/10481/72568 | |
dc.description | This study was supported by the grant #3650 managed by Fundacion General EmpresaUniversidad de Granada and by the investigation group CTS-454 "Impacto fisiologico del estres oxidativo, deporte, actividad fisica y salud". | es_ES |
dc.description.abstract | We tested whether physiological doses of hydroxytyrosol (HT) may alter the mRNA transcription of key metabolic genes in exercised skeletal muscle. Two groups of exercise-trained Wistar rats, HTlow and HTmid, were supplemented with 0.31 and 4.61 mg/kg/d of HT, respectively, for 10 weeks. Another two groups of rats were not supplemented with HT; one remained sedentary and the other one was exercised. After the experimental period, the soleus muscle was removed for qRT-PCR and western blot analysis. The consumption of 4.61 mg/kg/d of HT during exercise increased the mRNA expression of important metabolic proteins. Specifically, 4.61 mg/kg/d of HT may upregulate long-chain fatty acid oxidation, lactate, and glucose oxidation as well as mitochondrial Krebs cycle in trained skeletal muscle. However, a 4.61 mg/kg/d of HT may alter protein translation, as in spite of the increment showed by CD36 and GLUT4 at the mRNA level this was not translated to higher protein content. | es_ES |
dc.description.sponsorship | 3650 CTS-454 | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | MDPI | es_ES |
dc.rights | Atribución 3.0 España | * |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
dc.subject | Polyphenols | es_ES |
dc.subject | Mitochondria | es_ES |
dc.subject | Glycolysis | es_ES |
dc.subject | Gene expression | es_ES |
dc.title | Physiological Doses of Hydroxytyrosol Modulate Gene Expression in Skeletal Muscle of Exercised Rats | es_ES |
dc.type | journal article | es_ES |
dc.rights.accessRights | open access | es_ES |
dc.identifier.doi | 10.3390/life11121393 | |
dc.type.hasVersion | VoR | es_ES |