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dc.contributor.authorPérez González, Noelia
dc.contributor.authorNardi Ricart, Anna
dc.contributor.authorSoriano Ruiz, José Luis
dc.contributor.authorClares Naveros, Beatriz
dc.identifier.citationPérez-González, N... [et al.]. New Formulations Loading Caspofungin for Topical Therapy of Vulvovaginal Candidiasis. Gels 2021, 7, 259. []es_ES
dc.descriptionThis research was funded by the Spanish National Research Council (CSIC), project no. 202080E231, and the Agreement with the University of Barcelona and the University of Granada (Official State Gazette 311, on 27 November 2020).es_ES
dc.description.abstractVulvovaginal candidiasis (VVC) poses a significant problem worldwide affecting women from all strata of society. It is manifested as changes in vaginal discharge, irritation, itching and stinging sensation. Although most patients respond to topical treatment, there is still a need for increase the therapeutic arsenal due to resistances to anti-infective agents. The present study was designed to develop and characterize three hydrogels of chitosan (CTS), Poloxamer 407 (P407) and a combination of both containing 2% caspofungin (CSP) for the vaginal treatment of VVC. CTS was used by its mucoadhesive properties and P407 was used to exploit potential advantages related to increasing drug concentration in order to provide a local effect. The formulations were physically, mechanically and morphologically characterized. Drug release profile and ex vivo vaginal permeation studies were performed. Antifungal efficacy against different strains of Candida spp. was also evaluated. In addition, tolerance of formulations was studied by histological analysis. Results confirmed that CSP hydrogels could be proposed as promising candidates for the treatment of VVC.es_ES
dc.description.sponsorshipSpanish National Research Council (CSIC), project no. 202080E231es_ES
dc.description.sponsorshipAgreement with the University of Barcelona and the University of Granadaes_ES
dc.rightsAtribución 3.0 España*
dc.subjectVulvovaginal candidiasises_ES
dc.subjectAntifungal therapyes_ES
dc.subjectVaginal mucosal deliveryes_ES
dc.subjectMucoadhesive hydrogeles_ES
dc.subjectThermoreversible hydrogeles_ES
dc.titleNew Formulations Loading Caspofungin for Topical Therapy of Vulvovaginal Candidiasises_ES

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Atribución 3.0 España
Except where otherwise noted, this item's license is described as Atribución 3.0 España