Impaired Antioxidant Defence Status Is Associated With Metabolic-Inflammatory Risk Factors in Preterm Children With Extrauterine Growth Restriction: The BIORICA Cohort Study
Metadatos
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Frontiers
Materia
Prematurity Extrauterine growth restriction (EUGR) Antioxidants Catalase (CAT) Glutathione peroxidase (GPx) Glutathione reductase (GR) Superoxide dismutase (SOD) Children
Fecha
2021-12-21Referencia bibliográfica
Ordóñez-Díaz MD... [et al.] (2021) Impaired Antioxidant Defence Status Is Associated With Metabolic-Inflammatory Risk Factors in Preterm Children With Extrauterine Growth Restriction: The BIORICA Cohort Study. Front. Nutr. 8:793862. doi: [10.3389/fnut.2021.793862]
Patrocinador
Plan Nacional de Investigacion Cientifica, Desarrollo e Innovacion Tecnologica; Instituto de Salud Carlos III-Fondo de Investigacion Sanitaria Project Spanish Ministry of Health and; Consumer Affairs PI13/01245; Junta de Andalucia PI-0480-2012; Research Plan of the ViceRectorate of Research and Transfer of the University of Granada, Spain; Biomedicine Program at the University of Cordoba, Spain; Maternal-Infant and Developmental Health Network (SAMID); RETICS Carlos III Health Institute (ISCIII), Madrid, Spain Red SAMID RD12/0026/0015Resumen
Introduction: An impaired antioxidant status has been described during foetal growth restriction (FGR). Similarly, the antioxidant defence system can be compromised in preterm children with extrauterine growth restriction (EUGR). The aim of this prospective study was to evaluate the antioxidant status in prepubertal children with a history of prematurity without FGR, with and without EUGR, compared to a healthy group.Methods: In total, 211 children were recruited and classified into three groups: 38 with a history of prematurity and EUGR; 50 with a history of prematurity and adequate extrauterine growth (AEUG); and 123 control children born at term. Catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GPx) and glutathione reductase (GR) activities were assessed in lysed erythrocytes with spectrophotometric methods. Plasma levels of the antioxidants alpha-tocopherol, retinol and beta-carotene were determined through solvent extraction and ultra-high-pressure liquid chromatography coupled to mass spectrometry.Results: Children with the antecedent of EUGR and prematurity had lower CAT activity than the other two groups and lower GPx activity than the control children. Lower SOD, GPx and GR activities were observed in the AEUG group compared to the controls. However, higher concentrations of alpha-tocopherol and beta-carotene were found in the EUGR group compared to the other groups; retinol levels were also higher in EUGR than in AEUG children. In EUGR and AEUG children, enzymatic antioxidant activities and plasma antioxidants were associated with metabolic syndrome components and pro-inflammatory biomarkers.Conclusions: This study reveals, for the first time, that the EUGR condition and prematurity appear to be linked to an impairment of the antioxidant defence status, which might condition an increased risk of adverse metabolic outcomes later in life.