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dc.contributor.authorGarcía García, Amalia 
dc.contributor.authorRojas Macías, Sara 
dc.contributor.authorRivas García, Lorenzo
dc.contributor.authorNavarro Hortal, María Dolores 
dc.contributor.authorRomero Márquez, José Manuel 
dc.contributor.authorChoquesillo Lazarte, Duane
dc.contributor.authorSalinas Castillo, Alfonso 
dc.contributor.authorQuiles Morales, José Luis 
dc.contributor.authorRodríguez Diéguez, Antonio 
dc.date.accessioned2022-01-31T07:34:50Z
dc.date.available2022-01-31T07:34:50Z
dc.date.issued2021-12-16
dc.identifier.citationChem. Commun., 2022, Advance Article. DOI: [10.1039/d1cc04404d]es_ES
dc.identifier.urihttp://hdl.handle.net/10481/72538
dc.descriptionThe authors gratefully acknowledge funding support from the Spanish Ministry of Science, Innovation and Universities (PGC2018-102052-B-C21 and PID2020-116460RB-I00) and the Junta de Andaluci ' a (FQM-394 and FQM-134). The authors gratefully acknowledge the funding support of FEDER/Junta de Andaluci ' a Consejeri ' a de Economi ' a y Conocimiento, Grant B-AGR-193-UGR18. O. L. and J. G. F. B. also thank Grant PID2020-116460RB-I00 funded by MCIN/AEI/10.13039/50110 0011033. S. R. acknowledge the Juan de la Cierva Fellowship (IJC2019-038894-I). Mari ' a D. Navarro-Hortal and Jose M. Romero-Ma ' rquez are FPU fellows from the Spanish Ministry of Educacio ' n y Formacio ' n Profesional.es_ES
dc.description.abstractA new palladium coordination compound based on gliclazide with the chemical formula [Pd(glz)(2)] (where glz = gliclazide) has been synthesized and characterised. The structural characterization reveals that this material consists of mononuclear units formed by a Pd2+ ion coordinated to two molecules of the glz ligand, in which palladium ions exhibit a distorted plane-square coordination sphere. This novel material behaves like a good and selective inhibitor of butyrylcholinesterase, one of the most relevant therapeutic targets against Alzheimer's disease. Analysis of the enzyme kinetics showed a mixed mode of inhibition, the title compound being capable of interacting with both the free enzyme and the enzyme-substrate complex. Finally, the palladium compound shows promising protective activity against A beta-induced toxicity in the Caenorhabditis elegans model, which has never been reported.es_ES
dc.description.sponsorshipSpanish Government PGC2018-102052-B-C21 PID2020-116460RB-I00es_ES
dc.description.sponsorshipJunta de Andalucia FQM-394 FQM-134es_ES
dc.description.sponsorshipFEDER/Junta de Andaluci'a Consejeri'a de Economi'a y Conocimiento B-AGR-193-UGR18es_ES
dc.description.sponsorshipMCIN/AEI/ PID2020-116460RB-I00es_ES
dc.description.sponsorshipJuan de la Cierva Fellowship IJC2019-038894-Ies_ES
dc.language.isoenges_ES
dc.publisherRoyal Society of Chemistryes_ES
dc.rightsAtribución-NoComercial 3.0 España*
dc.rights.urihttp://creativecommons.org/licenses/by-nc/3.0/es/*
dc.titleA gliclazide complex based on palladium towards Alzheimer's disease: promising protective activity against A beta-induced toxicity in C. eleganses_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES
dc.identifier.doi10.1039/d1cc04404d
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersiones_ES


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