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A gliclazide complex based on palladium towards Alzheimer's disease: promising protective activity against A beta-induced toxicity in C. elegans
dc.contributor.author | García García, Amalia | |
dc.contributor.author | Rojas Macías, Sara | |
dc.contributor.author | Rivas García, Lorenzo | |
dc.contributor.author | Navarro Hortal, María Dolores | |
dc.contributor.author | Romero Márquez, José Manuel | |
dc.contributor.author | Choquesillo Lazarte, Duane | |
dc.contributor.author | Salinas Castillo, Alfonso | |
dc.contributor.author | Quiles Morales, José Luis | |
dc.contributor.author | Rodríguez Diéguez, Antonio | |
dc.date.accessioned | 2022-01-31T07:34:50Z | |
dc.date.available | 2022-01-31T07:34:50Z | |
dc.date.issued | 2021-12-16 | |
dc.identifier.citation | Chem. Commun., 2022, Advance Article. DOI: [10.1039/d1cc04404d] | es_ES |
dc.identifier.uri | http://hdl.handle.net/10481/72538 | |
dc.description | The authors gratefully acknowledge funding support from the Spanish Ministry of Science, Innovation and Universities (PGC2018-102052-B-C21 and PID2020-116460RB-I00) and the Junta de Andaluci ' a (FQM-394 and FQM-134). The authors gratefully acknowledge the funding support of FEDER/Junta de Andaluci ' a Consejeri ' a de Economi ' a y Conocimiento, Grant B-AGR-193-UGR18. O. L. and J. G. F. B. also thank Grant PID2020-116460RB-I00 funded by MCIN/AEI/10.13039/50110 0011033. S. R. acknowledge the Juan de la Cierva Fellowship (IJC2019-038894-I). Mari ' a D. Navarro-Hortal and Jose M. Romero-Ma ' rquez are FPU fellows from the Spanish Ministry of Educacio ' n y Formacio ' n Profesional. | es_ES |
dc.description.abstract | A new palladium coordination compound based on gliclazide with the chemical formula [Pd(glz)(2)] (where glz = gliclazide) has been synthesized and characterised. The structural characterization reveals that this material consists of mononuclear units formed by a Pd2+ ion coordinated to two molecules of the glz ligand, in which palladium ions exhibit a distorted plane-square coordination sphere. This novel material behaves like a good and selective inhibitor of butyrylcholinesterase, one of the most relevant therapeutic targets against Alzheimer's disease. Analysis of the enzyme kinetics showed a mixed mode of inhibition, the title compound being capable of interacting with both the free enzyme and the enzyme-substrate complex. Finally, the palladium compound shows promising protective activity against A beta-induced toxicity in the Caenorhabditis elegans model, which has never been reported. | es_ES |
dc.description.sponsorship | Spanish Government PGC2018-102052-B-C21 PID2020-116460RB-I00 | es_ES |
dc.description.sponsorship | Junta de Andalucia FQM-394 FQM-134 | es_ES |
dc.description.sponsorship | FEDER/Junta de Andaluci'a Consejeri'a de Economi'a y Conocimiento B-AGR-193-UGR18 | es_ES |
dc.description.sponsorship | MCIN/AEI/ PID2020-116460RB-I00 | es_ES |
dc.description.sponsorship | Juan de la Cierva Fellowship IJC2019-038894-I | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Royal Society of Chemistry | es_ES |
dc.rights | Atribución-NoComercial 3.0 España | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc/3.0/es/ | * |
dc.title | A gliclazide complex based on palladium towards Alzheimer's disease: promising protective activity against A beta-induced toxicity in C. elegans | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es_ES |
dc.identifier.doi | 10.1039/d1cc04404d | |
dc.type.hasVersion | info:eu-repo/semantics/publishedVersion | es_ES |