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dc.contributor.authorPadillo Ruiz, Javier
dc.contributor.authorSerrano Fernández, María José 
dc.date.accessioned2022-01-27T12:17:11Z
dc.date.available2022-01-27T12:17:11Z
dc.date.issued2021-12-07
dc.identifier.citationPadillo-Ruiz, J... [et al.]. Circulating Tumor Cells Enumeration from the Portal Vein for Risk Stratification in Early Pancreatic Cancer Patients. Cancers 2021, 13, 6153. [https://doi.org/10.3390/cancers13246153]es_ES
dc.identifier.urihttp://hdl.handle.net/10481/72523
dc.descriptionThis research was funded by Carlos III Health Institute (Health Research Fund) grant number PI16/01465 and PI19/01821 (Co-financed by the European Regional Development Fund "A way to make Europe").es_ES
dc.description.abstractBackground. Effective biomarkers are needed to enable personalized medicine for pancreatic cancer patients. This study analyzes the prognostic value, in early pancreatic cancer, of single circulating tumor cell (CTC) and CTC clusters from the central venous catheter (CVC) and portal blood (PV). Methods. In total, 7 mL of PV and CVC blood from 35 patients with early pancreatic cancer were analyzed. CTC were isolated using a positive immunomagnetic selection. The detection and identification of CTC were performed by immunocytochemistry (ICC) and were analyzed by Epi-fluorescence and confocal microscopy. Results. CTC and the clusters were detected both in PV and CVC. In both samples, the CTC number per cluster was higher in patients with grade three or poorly differentiated tumors (G3) than in patients with well (G1) or moderately (G2) differentiated. Patients with fewer than 185 CTC in PV exhibited a longer OS than patients with more than 185 CTC (24.5 vs. 10.0 months; p = 0.018). Similarly, patients with fewer than 15 clusters in PV showed a longer OS than patients with more than 15 clusters (19 vs. 10 months; p = 0.004). These significant correlations were not observed in CVC analyses. Conclusions. CTC presence in PV could be an important prognostic factor to predict poor prognosis in early pancreatic cancer. In addition, the number of clustered-CTC correlate to a tumor negative differentiation degree and, therefore, could be used as a diagnostic biomarker for pancreatic cancer.es_ES
dc.description.sponsorshipCarlos III Health Institute (Health Research Fund) (European Regional Development Fund "A way to make Europe") PI16/01465 PI19/01821es_ES
dc.language.isoenges_ES
dc.publisherMDPIes_ES
dc.rightsAtribución 3.0 España*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es/*
dc.subjectCirculating tumor celles_ES
dc.subjectClusteres_ES
dc.subjectPortal veines_ES
dc.subjectCentral venous catheteres_ES
dc.subjectPancreatic canceres_ES
dc.subjectEarly stagees_ES
dc.subjectDeath risk stratificationes_ES
dc.titleCirculating Tumor Cells Enumeration from the Portal Vein for Risk Stratification in Early Pancreatic Cancer Patientses_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES
dc.identifier.doi10.3390/cancers13246153
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersiones_ES


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Atribución 3.0 España
Except where otherwise noted, this item's license is described as Atribución 3.0 España