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dc.contributor.authorHis, Mathilde
dc.contributor.authorSánchez Pérez, María José
dc.identifier.citationHis, M... [et al.]. Lifestyle correlates of eight breast cancer-related metabolites: a cross-sectional study within the EPIC cohort. BMC Med 19, 312 (2021). []es_ES
dc.descriptionThis work was funded by the French National Cancer Institute (grant number 2015-166). Mathilde His' work reported here was undertaken during the tenure of a postdoctoral fellowship awarded by the International Agency for Research on Cancer, financed by the Fondation ARC. The coordination of EPIC is financially supported by International Agency for Research on Cancer (IARC) and also by the Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, which has additional infrastructure support provided by the NIHR Imperial Biomedical Research Centre (BRC). The national cohorts are supported by Danish Cancer Society (Denmark); Ligue Contre le Cancer, Institut Gustave Roussy, Mutuelle Generale de l'Education Nationale, Institut National de la Sante et de la Recherche Medicale (INSERM) (France); German Cancer Aid, German Cancer Research Center (DKFZ), German Institute of Human Nutrition Potsdam-Rehbruecke (DIfE), Federal Ministry of Education and Research (BMBF) (Germany); Associazione Italiana per la Ricerca sul Cancro-AIRC-Italy, Compagnia di SanPaolo and National Research Council (Italy); Dutch Ministry of Public Health, Welfare and Sports (VWS), LK Research Funds, Dutch Prevention Funds, Dutch ZON (Zorg Onderzoek Nederland), World Cancer Research Fund (WCRF) (The Netherlands); Health Research Fund (FIS) - Instituto de Salud Carlos III (ISCIII), Regional Governments of Andalucia, Asturias, Basque Country, Murcia and Navarra, and the Catalan Institute of Oncology-ICO (Spain); Swedish Cancer Society, Swedish Research Council and County Councils of Skane and Vasterbotten (Sweden); and Cancer Research UK (14136 to EPIC-Norfolk (DOI 10.22025/2019.10.105.00004); C8221/A29017 to EPIC-Oxford), Medical Research Council (1000143, MR/N003284/1, MC-UU_12015/1 and MC_UU_00006/1 to EPIC-Norfolk; MR/M012190/1 to EPIC-Oxford) (UK). The funders were not involved in designing the study; collecting, analyzing, or interpreting the data; or writing or submitting the manuscript for publication.es_ES
dc.description.abstractBackground: Metabolomics is a promising molecular tool for identifying novel etiological pathways leading to cancer. In an earlier prospective study among pre- and postmenopausal women not using exogenous hormones, we observed a higher risk of breast cancer associated with higher blood concentrations of one metabolite (acetylcarnitine) and a lower risk associated with higher blood concentrations of seven others (arginine, asparagine, phosphatidylcholines (PCs) aa C36:3, ae C34:2, ae C36:2, ae C36:3, and ae C38:2). Methods: To identify determinants of these breast cancer-related metabolites, we conducted a cross-sectional analysis to identify their lifestyle and anthropometric correlates in 2358 women, who were previously included as controls in case-control studies nested within the European Prospective Investigation into Cancer and Nutrition cohort and not using exogenous hormones at blood collection. Associations of each metabolite concentration with 42 variables were assessed using linear regression models in a discovery set of 1572 participants. Significant associations were evaluated in a validation set (n = 786). Results: For the metabolites previously associated with a lower risk of breast cancer, concentrations of PCs ae C34: 2, C36:2, C36:3, and C38:2 were negatively associated with adiposity and positively associated with total and saturated fat intakes. PC ae C36:2 was also negatively associated with alcohol consumption and positively associated with two scores reflecting adherence to a healthy lifestyle. Asparagine concentration was negatively associated with adiposity. Arginine and PC aa C36:3 concentrations were not associated to any of the factors examined. For the metabolite previously associated with a higher risk of breast cancer, acetylcarnitine, a positive association with age was observed. Conclusions: These associations may indicate possible mechanisms underlying associations between lifestyle and anthropometric factors, and risk of breast cancer. Further research is needed to identify potential non-lifestyle correlates of the metabolites investigated.es_ES
dc.description.sponsorshipInstitut National du Cancer (INCA) France 2015-166es_ES
dc.description.sponsorshipInternational Agency for Research on Cancer - Fondation ARCes_ES
dc.description.sponsorshipWorld Health Organizationes_ES
dc.description.sponsorshipDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College Londones_ES
dc.description.sponsorshipDanish Cancer Societyes_ES
dc.description.sponsorshipLigue Contre le Cancer (France)es_ES
dc.description.sponsorshipInstitut Gustave Roussy (France)es_ES
dc.description.sponsorshipMutuelle Generale de l'Education Nationale (France)es_ES
dc.description.sponsorshipInstitut National de la Sante et de la Recherche Medicale (Inserm)es_ES
dc.description.sponsorshipDeutsche Krebshilfees_ES
dc.description.sponsorshipGerman Cancer Research Center (DKFZ) (Germany)es_ES
dc.description.sponsorshipGerman Institute of Human Nutrition Potsdam-Rehbruecke (DIfE) (Germany)es_ES
dc.description.sponsorshipFederal Ministry of Education & Research (BMBF)es_ES
dc.description.sponsorshipFondazione AIRC per la ricerca sul cancroes_ES
dc.description.sponsorshipCompagnia di San Paoloes_ES
dc.description.sponsorshipConsiglio Nazionale delle Ricerche (CNR)es_ES
dc.description.sponsorshipNetherlands Governmentes_ES
dc.description.sponsorshipWorld Cancer Research Fund International (WCRF)es_ES
dc.description.sponsorshipHealth Research Fund (FIS) - Instituto de Salud Carlos III (ISCIII) (Spain)es_ES
dc.description.sponsorshipJunta de Andaluciaes_ES
dc.description.sponsorshipRegional Government of Asturias (Spain)es_ES
dc.description.sponsorshipRegional Government of Basque Country (Spain)es_ES
dc.description.sponsorshipRegional Government of Murcia (Spain)es_ES
dc.description.sponsorshipRegional Government of Navarra (Spain)es_ES
dc.description.sponsorshipCatalan Institute of Oncology-ICO (Spain)es_ES
dc.description.sponsorshipSwedish Cancer Societyes_ES
dc.description.sponsorshipSwedish Research Counciles_ES
dc.description.sponsorshipCounty Council of Skane (Sweden)es_ES
dc.description.sponsorshipCounty Council of Vasterbotten (Sweden)es_ES
dc.description.sponsorshipCancer Research UK 14136 C8221/A29017es_ES
dc.description.sponsorshipUK Research & Innovation (UKRI)es_ES
dc.description.sponsorshipMedical Research Council UK (MRC) 1000143 MR/N003284/1 MC-UU_12015/1 MC_UU_00006/1 MR/M012190/1es_ES
dc.rightsAtribución 3.0 España*
dc.subjectBreast canceres_ES
dc.subjectAnthropometry es_ES
dc.titleLifestyle correlates of eight breast cancerrelated metabolites: a cross-sectional study within the EPIC cohortes_ES

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Atribución 3.0 España
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