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dc.contributor.authorRipoll, Consuelo
dc.contributor.authorRoldan, Mar
dc.contributor.authorRuedas Rama, María José 
dc.contributor.authorOrte Gutiérrez, Ángel 
dc.contributor.authorMartín Hernández, Miguel
dc.identifier.citationRipoll, C.; Roldan, M.; Ruedas-Rama, M.J.; Orte, A.; Martin, M. Breast Cancer Cell Subtypes Display Different Metabolic Phenotypes That Correlate with Their Clinical Classification. Biology 2021, 10, 1267. biology10121267es_ES
dc.description.abstractRecent studies on cancer cell metabolism have achieved notable breakthroughs that have led to a new scientific paradigm. How cancer cell metabolic reprogramming is orchestrated and the decisive role of this reprogramming in the oncogenic process and tumor adaptative evolution has been characterized at the molecular level. Despite this knowledge, it is essential to understand how cancer cells can metabolically respond as a living whole to ensure their survival and adaptation potential. In this work, we investigated whether different cancers and different subtypes display different metabolic phenotypes with a focus on breast cancer cell models representative of each clinical subtype. The potential results might have significant translational implications for diagnostic, prognostic and therapeutic applications.es_ES
dc.description.abstractMetabolic reprogramming of cancer cells represents an orchestrated network of evolving molecular and functional adaptations during oncogenic progression. In particular, how metabolic reprogramming is orchestrated in breast cancer and its decisive role in the oncogenic process and tumor evolving adaptations are well consolidated at the molecular level. Nevertheless, potential correlations between functional metabolic features and breast cancer clinical classification still represent issues that have not been fully studied to date. Accordingly, we aimed to investigate whether breast cancer cell models representative of each clinical subtype might display different metabolic phenotypes that correlate with current clinical classifications. In the present work, functional metabolic profiling was performed for breast cancer cell models representative of each clinical subtype based on the combination of enzyme inhibitors for key metabolic pathways, and isotope-labeled tracing dynamic analysis. The results indicated the main metabolic phenotypes, so-called ‘metabophenotypes’, in terms of their dependency on glycolytic metabolism or their reliance on mitochondrial oxidative metabolism. The results showed that breast cancer cell subtypes display different metabophenotypes. Importantly, these metabophenotypes are clearly correlated with the current clinical classifications.es_ES
dc.description.sponsorshipSpanish Agencia Estatal de Investigación (Ministry of Science and Innovation)es_ES
dc.description.sponsorshipEuropean Regional Development Fund [grant numbers CTQ2014-56370-R and CTQ2017-85658-R]es_ES
dc.description.sponsorshipFundación Ramón Areceses_ES
dc.description.sponsorshipInitiative "Solidaridad Entre Montañas"es_ES
dc.rightsAtribución 3.0 España*
dc.subjectMetabolic profilinges_ES
dc.subjectBreast canceres_ES
dc.subjectTumor metabolismes_ES
dc.subjectMetabolic reprogramminges_ES
dc.titleBreast Cancer Cell Subtypes Display Different Metabolic Phenotypes That Correlate with Their Clinical Classificationes_ES
dc.identifier.doi10.3390/ biology10121267

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Atribución 3.0 España
Except where otherwise noted, this item's license is described as Atribución 3.0 España