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dc.contributor.authorToledano Osorio, Manuel 
dc.contributor.authorOsorio Ruiz, Raquel 
dc.contributor.authorOsorio Ruiz, María Estrella 
dc.contributor.authorMedina Castillo, Antonio Luis 
dc.contributor.authorToledano Pérez, Manuel
dc.identifier.citationToledano-Osorio, M.; Osorio, R.; Osorio, E.; Medina-Castillo, A.L.; Toledano, M. Novel Pastes Containing Polymeric Nanoparticles for Dentin Hypersensitivity Treatment: An In Vitro Study. Nanomaterials 2021, 11, 3150. nano11113150es_ES
dc.description.abstractTubule occlusion and remineralization are considered the two main goals of dentin hypersensitivity treatment. The objective is to assess the ability of dentifrices containing zinc-doped polymeric nanoparticles (NPs) to enduringly occlude the dentinal tubules, reinforcing dentin’s mechanical properties. Fifteen dentin surfaces were acid-treated for dentinal tubule exposure and brushed with (1) distilled water, or with experimental pastes containing (2) 1% of zinc-doped NPs, (3) 5% of zinc-doped NPs, (4) 10% of zinc-doped NPs or (5) Sensodyne®. Topographical and nanomechanical analyses were performed on treated dentin surfaces and after a citric acid challenge. ANOVA and Student–Newman–Keuls tests were used (p < 0.05). The main results indicate that all pastes produced tubule occlusion (100%) and reinforced mechanical properties of intertubular dentin (complex modulus was above 75 GPa). After the citric acid challenge, only those pastes containing zinc-doped NPs were able to maintain tubular occlusion, as specimens treated with Sensodyne® have around 30% of tubules opened. Mechanical properties were maintained for dentin treated with Zn-doped NPs, but in the case of specimens treated with Sensodyne®, complex modulus values were reduced below 50 GPa. It may be concluded that zinc-doped NPs at the lowest tested concentration produced acid-resistant tubular occlusion and increased the mechanical properties of dentin.es_ES
dc.description.sponsorshipMinistry of Economy and Competitiveness (MINECO) and European Regional Development Fund (FEDER), grant number PID2020-114694RB-I00 MINECO/AEI/ FEDER/UEes_ES
dc.description.sponsorshipLaboratorios KIN® fabricated and provided tested experimental pastes loaded with Zn-doped NPses_ES
dc.rightsAtribución 3.0 España*
dc.subjectZinc es_ES
dc.subjectDentin hypersensitivityes_ES
dc.subjectDentinal tubuleses_ES
dc.titleNovel Pastes Containing Polymeric Nanoparticles for Dentin Hypersensitivity Treatment: An In Vitro Studyes_ES

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Atribución 3.0 España
Except where otherwise noted, this item's license is described as Atribución 3.0 España