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Novel Pastes Containing Polymeric Nanoparticles for Dentin Hypersensitivity Treatment: An In Vitro Study
dc.contributor.author | Toledano Osorio, Manuel | |
dc.contributor.author | Osorio Ruiz, Raquel | |
dc.contributor.author | Osorio Ruiz, María Estrella | |
dc.contributor.author | Medina Castillo, Antonio Luis | |
dc.contributor.author | Toledano Pérez, Manuel | |
dc.date.accessioned | 2021-11-23T12:06:41Z | |
dc.date.available | 2021-11-23T12:06:41Z | |
dc.date.issued | 2021 | |
dc.identifier.citation | Toledano-Osorio, M.; Osorio, R.; Osorio, E.; Medina-Castillo, A.L.; Toledano, M. Novel Pastes Containing Polymeric Nanoparticles for Dentin Hypersensitivity Treatment: An In Vitro Study. Nanomaterials 2021, 11, 3150. https://doi.org/10.3390/ nano11113150 | es_ES |
dc.identifier.uri | http://hdl.handle.net/10481/71695 | |
dc.description.abstract | Tubule occlusion and remineralization are considered the two main goals of dentin hypersensitivity treatment. The objective is to assess the ability of dentifrices containing zinc-doped polymeric nanoparticles (NPs) to enduringly occlude the dentinal tubules, reinforcing dentin’s mechanical properties. Fifteen dentin surfaces were acid-treated for dentinal tubule exposure and brushed with (1) distilled water, or with experimental pastes containing (2) 1% of zinc-doped NPs, (3) 5% of zinc-doped NPs, (4) 10% of zinc-doped NPs or (5) Sensodyne®. Topographical and nanomechanical analyses were performed on treated dentin surfaces and after a citric acid challenge. ANOVA and Student–Newman–Keuls tests were used (p < 0.05). The main results indicate that all pastes produced tubule occlusion (100%) and reinforced mechanical properties of intertubular dentin (complex modulus was above 75 GPa). After the citric acid challenge, only those pastes containing zinc-doped NPs were able to maintain tubular occlusion, as specimens treated with Sensodyne® have around 30% of tubules opened. Mechanical properties were maintained for dentin treated with Zn-doped NPs, but in the case of specimens treated with Sensodyne®, complex modulus values were reduced below 50 GPa. It may be concluded that zinc-doped NPs at the lowest tested concentration produced acid-resistant tubular occlusion and increased the mechanical properties of dentin. | es_ES |
dc.description.sponsorship | Ministry of Economy and Competitiveness (MINECO) and European Regional Development Fund (FEDER), grant number PID2020-114694RB-I00 MINECO/AEI/ FEDER/UE | es_ES |
dc.description.sponsorship | Laboratorios KIN® fabricated and provided tested experimental pastes loaded with Zn-doped NPs | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | MDPI | es_ES |
dc.rights | Atribución 3.0 España | * |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
dc.subject | Nanoparticles | es_ES |
dc.subject | Zinc | es_ES |
dc.subject | Dentin hypersensitivity | es_ES |
dc.subject | Dentinal tubules | es_ES |
dc.subject | Dentifrice | es_ES |
dc.title | Novel Pastes Containing Polymeric Nanoparticles for Dentin Hypersensitivity Treatment: An In Vitro Study | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es_ES |
dc.identifier.doi | 10.3390/nano11113150 |