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dc.contributor.authorGonzález García, María del Carmen 
dc.contributor.authorSalto Girón, Carmen
dc.contributor.authorHerrero-Foncubierta, Pilar
dc.contributor.authorPeña-Ruiz, Tomás
dc.contributor.authorGirón González, María Dolores 
dc.contributor.authorSalto González, Rafael 
dc.contributor.authorPérez Lara, Francisco Ángel 
dc.contributor.authorNavarro, A
dc.contributor.authorGarcía-Fernández, Emilio
dc.contributor.authorOrte Gutiérrez, Ángel 
dc.date.accessioned2021-11-17T11:36:26Z
dc.date.available2021-11-17T11:36:26Z
dc.date.issued2021-09-09
dc.identifier.citationACS Sens. 2021, 6, 10, 3632–3639 Publication Date:September 9, 2021 [https://doi.org/10.1021/acssensors.1c01206]es_ES
dc.identifier.urihttp://hdl.handle.net/10481/71579
dc.descriptionThis work was funded by grants CTQ2017-85658-R (MICIU/AEI/ERDF), FQM-337 (Junta de Andalucía), and PIUJA 2019-20 (Universidad de Jaén). We acknowledge the Universidad de Granada (Spain) microscopy central facilities (CIC-UGR) and computing time from CSIRC-UGR. M.C.G.-G. thanks MICIU/AEI for a predoctoral fellowship. Funding for open access charge: Universidad de Granada/CBUA. We are indebted to Prof. Reinhard Jahn for his generous support.es_ES
dc.description.abstractUnraveling cellular physiological processes via luminescent probes that target specific cellular microenvironments is quite challenging due to the uneven distribution of probes. Herein, we designed a new dynamic excimer (DYNEX) imaging method that involves the sensitive detection of nanosecond-scale dynamic molecular contacts of a fluorescent acridone derivative and reveals the cell microenvironment polarity. Using our method, we specifically tracked cell lipid droplets in fibroblast colon carcinoma cells. These organelles play a central role in metabolic pathways, acting as energy reservoirs in regulatory processes. DYNEX imaging provides the inner polarity of cell lipid droplets, which can be related to lipid contents and metabolic dysfunctions. This new methodology will inspire development of novel multidimensional fluorescent sensors that are able to provide target-specific and orthogonal information at the nanosecond scale.es_ES
dc.description.sponsorshipCBUAes_ES
dc.description.sponsorshipMICIUes_ES
dc.description.sponsorshipUniversidad de Granadaes_ES
dc.description.sponsorshipUniversidad de Jaénes_ES
dc.description.sponsorshipAgencia Estatal de Investigaciónes_ES
dc.description.sponsorshipEuropean Regional Development Fund FQM-337es_ES
dc.description.sponsorshipJunta de Andalucía PIUJA 2019-20es_ES
dc.language.isoenges_ES
dc.publisherAmerican Chemical Societyes_ES
dc.rightsAtribución 3.0 España*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es/*
dc.subjectCell microenvironmentes_ES
dc.subjectExcimer imaginges_ES
dc.subjectFluorescent probeses_ES
dc.subjectImaging agentses_ES
dc.subjectLipidses_ES
dc.subjectMultiparametric microscopyes_ES
dc.titleDynamic Excimer (DYNEX) Imaging of Lipid Dropletses_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES
dc.identifier.doi10.1021/acssensors.1c01206
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersiones_ES


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Atribución 3.0 España
Except where otherwise noted, this item's license is described as Atribución 3.0 España