Furosemide/Non-Steroidal Anti-Inflammatory Drug–Drug Pharmaceutical Solids: Novel Opportunities in Drug Formulation
MetadataShow full item record
AuthorAcebedo Martínez, Francisco Javier; Alarcón-Payer, Carolina; Rodríguez Domingo, Lucía; Domínguez Martín, Alicia; Gómez Morales, Jaime; Choquesillo Lazarte, Duane
Drug–drug cocrystalFurosemideEthenzamidePiroxicamMechanochemical synthesis
Acebedo-Martínez, F.J.; Alarcón-Payer, C.; RodríguezDomingo, L.; Domínguez-Martín, A.; Gómez-Morales, J.; ChoquesilloLazarte, D. Furosemide/NonSteroidal Anti-Inflammatory Drug–Drug Pharmaceutical Solids: Novel Opportunities in Drug Formulation. Crystals 2021, 11, 1339. https://doi.org/10.3390/ cryst11111339
Sponsorshipy Spanish Agencia Estatal de Investigación of the Ministerio de Ciencia, Innovación y Universidades (MICIU) and co-funded with FEDER, UE, Project No. PGC2018- 102047-B-I00 (MCIU/AEI/FEDER, UE) and Project No. B-FQM-478-UGR20 (FEDER-Universidad de Granada, Spain).
The design of drug–drug multicomponent pharmaceutical solids is one the latest drug development approaches in the pharmaceutical industry. Its purpose is to modulate the physicochemical properties of active pharmaceutical ingredients (APIs), most of them already existing in the market, achieving improved bioavailability properties, especially on oral administration drugs. In this work, our efforts are focused on the mechanochemical synthesis and thorough solid-state characterization of two drug–drug cocrystals involving furosemide and two different non-steroidal anti-inflammatory drugs (NSAIDs) commonly prescribed together: ethenzamide and piroxicam. Besides powder and single crystal X-ray diffraction, infrared spectroscopy and thermal analysis, stability, and solubility tests were performed on the new solid materials. The aim of this work was evaluating the physicochemical properties of such APIs in the new formulation, which revealed a solubility improvement regarding the NSAIDs but not in furosemide. Further studies need to be carried out to evaluate the drug–drug interaction in the novel multicomponent solids, looking for potential novel therapeutic alternatives.