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dc.contributor.authorOrtega Muñoz, Mariano 
dc.contributor.authorVargas Navarro, Paula
dc.contributor.authorPlesselova, Simona 
dc.contributor.authorGirón González, María Dolores 
dc.contributor.authorIglesias Salto, Guillermo Ramón 
dc.contributor.authorSalto González, Rafael 
dc.contributor.authorHernández Mateo, Fernando 
dc.contributor.authorDelgado Mora, Ángel Vicente 
dc.contributor.authorLópez Jaramillo, Javier 
dc.contributor.authorSantoyo González, Francisco
dc.identifier.citationMater. Chem. Front., 2021, Advance Article. DOI: [10.1039/d1qm00855b]es_ES
dc.descriptionThe work was financially supported by the Spanish institutions Ministerio de Ciencia, Innovacion y Universidades (PGC2018-098770-B-I00 and CTQ2017-86125-P) and Junta de Andalucia (ProgramaOperativo FEDER 2014-2020, grants B-FQM-141-UGR18, A1-FQM-341-UGR-18, C-FQM-497-UGR18).es_ES
dc.description.abstractWater-insoluble carbon dots are recognized as promising materials, although their applications in nanomedicine are rarely explored, despite their lipophilic character and foreseen compatibility with biological membranes. In this article, we exploit the anhydride functionalization of carbon dots obtained by thermolysis of citric acid to synthesize amphiphilic-like carbon dots (LCDs) by reaction with alkyl amines. A differential feature of this approach is that the hydrophobicity of LCDs is a balance between the ionization of the carboxylic groups resulting from the reaction and the hydrophobicity from the grafted amines. The alkyl chains allow LCDs to entrap hydrophobic molecules and the ionization of the carboxylic groups increases the hydrosolubility, permitting the transfer between organic and aqueous phases. The biomedical interest of these features is illustrated by analyzing the application of LCDs as carriers of the drug campothecin and their evaluation on a battery of cancer cell lines, as well as the transformation of LCDs into a phototherapeutic agent by the formation of a complex with IR780 dye. Results demonstrate that LCDs behave as nanocarriers in a manner that resembles other supramolecular hosts with two differential features: (i) the length of the alkyl chains determines the size of the hosted guest, and (ii) the hydrosolubility of the complex can be modulated by pH.es_ES
dc.description.sponsorshipMinisterio de Ciencia, Innovacion y Universidades PGC2018-098770-B-I00 CTQ2017-86125-Pes_ES
dc.description.sponsorshipJunta de Andalucia B-FQM-141-UGR18 A1-FQM-341-UGR-18 C-FQM-497-UGR18es_ES
dc.publisherRoyal Society of Chemistryes_ES
dc.rightsAtribución-NoComercial 3.0 España*
dc.titleAmphiphilic-like carbon dots as antitumoral drug vehicles and phototherapeutical agentses_ES

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Atribución-NoComercial 3.0 España
Except where otherwise noted, this item's license is described as Atribución-NoComercial 3.0 España