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dc.contributor.authorNavarro Hortal, María Dolores 
dc.contributor.authorRomero Márquez, José Manuel 
dc.contributor.authorEsteban Muñoz, Adelaida
dc.contributor.authorSánchez González, Cristina 
dc.contributor.authorRivas García, Lorenzo
dc.contributor.authorLlopis González, Juan 
dc.contributor.authorQuiles Morales, José Luis 
dc.date.accessioned2021-11-03T07:58:00Z
dc.date.available2021-11-03T07:58:00Z
dc.date.issued2021-10-01
dc.identifier.citationMaría D. Navarro-Hortal... [et al.]. Strawberry (Fragaria × ananassa cv. Romina) methanolic extract attenuates Alzheimer’s beta amyloid production and oxidative stress by SKN-1/NRF and DAF-16/FOXO mediated mechanisms in C. elegans, Food Chemistry, Volume 372, 2022, 131272, ISSN 0308-8146, [https://doi.org/10.1016/j.foodchem.2021.131272]es_ES
dc.identifier.urihttp://hdl.handle.net/10481/71237
dc.descriptionMaria D. Navarro-Hortal and Jose M. Romero-Marquez are FPU fellows from the Spanish Ministry of Educacion y Formacion Profesional. Funding for open access charge: Universidad de Granada/CBUA.es_ES
dc.description.abstractBioactive compounds from strawberries have been associated with multiple healthy benefits. The present study aimed to assess chemical characterization of a methanolic extract of the Romina strawberry variety in terms of antioxidant capacity, polyphenols profile and chemical elements content. Additionally, potential toxicity, the effect on amyloid-β production and oxidative stress of the extract was in vivo evaluated in the experimental model Caenorhabditis elegans. Results revealed an important content in phenolic compounds (mainly ellagic acid and pelargonidin-3-glucoside) and minerals (K, Mg, P and Ca). The treatment with 100, 500 or 1000 μg/mL of strawberry extract did not show toxicity. On the contrary, the extract was able to delay amyloid β-protein induced paralysis, reduced amyloid-β aggregation and prevented oxidative stress. The potential molecular mechanisms present behind the observed results explored by RNAi technology revealed that DAF-16/FOXO and SKN-1/NRF2 signaling pathways were, at least partially, involved.es_ES
dc.description.sponsorshipUniversidad de Granada/CBUAes_ES
dc.language.isoenges_ES
dc.publisherElsevieres_ES
dc.rightsAtribución-NoComercial-SinDerivadas 3.0 España*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es/*
dc.subjectBerrieses_ES
dc.subjectAntioxidants es_ES
dc.subjectAnthocyaninses_ES
dc.subjectMinerals es_ES
dc.subjectRNAies_ES
dc.subjectROSes_ES
dc.titleStrawberry (Fragaria × ananassa cv. Romina) methanolic extract attenuates Alzheimer’s beta amyloid production and oxidative stress by SKN-1/NRF and DAF-16/FOXO mediated mechanisms in C. eleganses_ES
dc.typejournal articlees_ES
dc.rights.accessRightsopen accesses_ES
dc.identifier.doi10.1016/j.foodchem.2021.131272
dc.type.hasVersionVoRes_ES


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