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Strawberry (Fragaria × ananassa cv. Romina) methanolic extract attenuates Alzheimer’s beta amyloid production and oxidative stress by SKN-1/NRF and DAF-16/FOXO mediated mechanisms in C. elegans
dc.contributor.author | Navarro Hortal, María Dolores | |
dc.contributor.author | Romero Márquez, José Manuel | |
dc.contributor.author | Esteban Muñoz, Adelaida | |
dc.contributor.author | Sánchez González, Cristina | |
dc.contributor.author | Rivas García, Lorenzo | |
dc.contributor.author | Llopis González, Juan | |
dc.contributor.author | Quiles Morales, José Luis | |
dc.date.accessioned | 2021-11-03T07:58:00Z | |
dc.date.available | 2021-11-03T07:58:00Z | |
dc.date.issued | 2021-10-01 | |
dc.identifier.citation | María D. Navarro-Hortal... [et al.]. Strawberry (Fragaria × ananassa cv. Romina) methanolic extract attenuates Alzheimer’s beta amyloid production and oxidative stress by SKN-1/NRF and DAF-16/FOXO mediated mechanisms in C. elegans, Food Chemistry, Volume 372, 2022, 131272, ISSN 0308-8146, [https://doi.org/10.1016/j.foodchem.2021.131272] | es_ES |
dc.identifier.uri | http://hdl.handle.net/10481/71237 | |
dc.description | Maria D. Navarro-Hortal and Jose M. Romero-Marquez are FPU fellows from the Spanish Ministry of Educacion y Formacion Profesional. Funding for open access charge: Universidad de Granada/CBUA. | es_ES |
dc.description.abstract | Bioactive compounds from strawberries have been associated with multiple healthy benefits. The present study aimed to assess chemical characterization of a methanolic extract of the Romina strawberry variety in terms of antioxidant capacity, polyphenols profile and chemical elements content. Additionally, potential toxicity, the effect on amyloid-β production and oxidative stress of the extract was in vivo evaluated in the experimental model Caenorhabditis elegans. Results revealed an important content in phenolic compounds (mainly ellagic acid and pelargonidin-3-glucoside) and minerals (K, Mg, P and Ca). The treatment with 100, 500 or 1000 μg/mL of strawberry extract did not show toxicity. On the contrary, the extract was able to delay amyloid β-protein induced paralysis, reduced amyloid-β aggregation and prevented oxidative stress. The potential molecular mechanisms present behind the observed results explored by RNAi technology revealed that DAF-16/FOXO and SKN-1/NRF2 signaling pathways were, at least partially, involved. | es_ES |
dc.description.sponsorship | Universidad de Granada/CBUA | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Elsevier | es_ES |
dc.rights | Atribución-NoComercial-SinDerivadas 3.0 España | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/es/ | * |
dc.subject | Berries | es_ES |
dc.subject | Antioxidants | es_ES |
dc.subject | Anthocyanins | es_ES |
dc.subject | Minerals | es_ES |
dc.subject | RNAi | es_ES |
dc.subject | ROS | es_ES |
dc.title | Strawberry (Fragaria × ananassa cv. Romina) methanolic extract attenuates Alzheimer’s beta amyloid production and oxidative stress by SKN-1/NRF and DAF-16/FOXO mediated mechanisms in C. elegans | es_ES |
dc.type | journal article | es_ES |
dc.rights.accessRights | open access | es_ES |
dc.identifier.doi | 10.1016/j.foodchem.2021.131272 | |
dc.type.hasVersion | VoR | es_ES |