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dc.contributor.authorPallante, Lorenzo
dc.contributor.authorMartos Núñez, María Vanesa 
dc.date.accessioned2021-10-29T06:20:58Z
dc.date.available2021-10-29T06:20:58Z
dc.date.issued2021-08-08
dc.identifier.citationLorenzo Pallante... [et al.]. On the human taste perception: Molecular-level understanding empowered by computational methods, Trends in Food Science & Technology, Volume 116, 2021, Pages 445-459, ISSN 0924-2244, [https://doi.org/10.1016/j.tifs.2021.07.013]es_ES
dc.identifier.urihttp://hdl.handle.net/10481/71159
dc.descriptionThe present review has been developed as part of the VIRTUOUS project, funded by the European Union's Horizon 2020 research and innovation program under the Marie Sklodowska-Curie-RISE Grant Agreement No 872181 (https://www.virtuoush2020.com/).es_ES
dc.description.abstractBackground: The perception of taste is a prime example of complex signal transduction at the subcellular level, involving an intricate network of molecular machinery, which can be investigated to great extent by the tools provided by Computational Molecular Modelling. The present review summarises the current knowledge on the molecular mechanisms at the root of taste transduction, in particular involving taste receptors, highly specialised proteins driving the activation/deactivation of specific cell signalling pathways and ultimately leading to the perception of the five principal tastes: sweet, umami, bitter, salty and sour. The former three are detected by similar G protein-coupled receptors, while the latter two are transduced by ion channels. Scope and approach: The main objective of the present review is to provide a general overview of the molecular structures investigated to date of all taste receptors and the techniques employed for their molecular modelling. In addition, we provide an analysis of the various ligands known to date for the above-listed receptors, including how they are activated in the presence of their target molecule. Key findings and conclusions: In the last years, numerous advances have been made in molecular research and computational investigation of ligand-receptor interaction related to taste receptors. This work aims to outline the progress in scientific knowledge about taste perception and understand the molecular mechanisms involved in the transfer of taste information.es_ES
dc.description.sponsorshipEuropean Union's Horizon 2020 research and innovation program under the Marie Sklodowska-Curie-RISE Grant 872181es_ES
dc.language.isoenges_ES
dc.publisherElsevieres_ES
dc.rightsAtribución-NoComercial-SinDerivadas 3.0 España*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es/*
dc.subjectTaste receptorses_ES
dc.subjectMolecular modellinges_ES
dc.subjectMolecular dynamics es_ES
dc.subjectTaste es_ES
dc.subjectGPCRes_ES
dc.subjectIon channeles_ES
dc.titleOn the human taste perception: Molecular-level understanding empowered by computational methodses_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/H2020/872181es_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES
dc.identifier.doi10.1016/j.tifs.2021.07.013
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersiones_ES


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