Efficacy of local antibiotic therapy in the treatment of peri-implantitis: A systematic review and meta-analysis
Metadatos
Mostrar el registro completo del ítemAutor
Toledano Pérez, Manuel; Vallecillo Rivas, Marta; Toledano Osorio, Manuel; Rodríguez Archilla, Alberto; Osorio Ruiz, RaquelEditorial
Elsevier
Materia
Anti-bacterial agents Bleeding on probing Peri-implantitits Probing pocket depth
Fecha
2021-08-27Referencia bibliográfica
Manuel Toledano... [et al.]. Efficacy of local antibiotic therapy in the treatment of peri-implantitis: A systematic review and meta-analysis, Journal of Dentistry, Volume 113, 2021, 103790, ISSN 0300-5712, [https://doi.org/10.1016/j.jdent.2021.103790]
Patrocinador
Ministry of Economy and Competitiveness PID2020-114694RB-I00; European Commission PID2020-114694RB-I00; University of Granada/CBUAResumen
Objectives: The aim of this systematic review and meta-analysis was to state the efficacy of local administration of
antibiotics in the treatment of peri-implantitis in terms of peri-implant probing depth (PPD) and bleeding on
probing (BoP) reduction.
Data, sources and study selection: Electronic and manual literature searches were conducted. Screening process
was done using the National Library of Medicine (MEDLINE by PubMed), Embase and the Cochrane Oral Health.
Included articles were randomized controlled trials and observational studies. Weighted means were calculated.
Heterogeneity was determined using Higgins (I2). Due to the encountered heterogeneity between the studies
being combined, random-effects models were applied in order to analyze effect sizes. Twelve studies (365 patients
and 463 implants) were included in the systematic review. After peri-implantitis treatment with local
antibiotics, PPD was reduced 1.40 mm (95% confidence interval: 0.82-1.98). When local antibiotics were
applied, a 0.30 mm higher reduction of PPD was obtained than in the control group (95% confidence interval:
0.07-0.53). BoP attained an odds ratio value of 1.82 (95% confidence interval: 1.09-3.04), indicating that the
likehood of bleeding is almost two-fold when antibiotics are not locally administrated. Adverse effects were not
found after applying local antibiotics.
Conclusions: The local antibiotic administration does reduce, without adverse effects, both peri-implant probing
depths and bleeding on probing in patients affected by peri-implantitis, if compared to control groups without
local antibiotic application.
Clinical significance: Patients with dental implants frequently suffer from peri-implantitis. Clinical features of periimplantitis
lesions include the presence of bleeding on probing and increased peri-implant probing depths. Both
BoP and PPD have become reduced after local administration of antibiotics.