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Untargeted Metabolomics for the Diagnosis of Exocrine Pancreatic Insufficiency in Chronic Pancreatitis
dc.contributor.author | Diaz, Caridad | |
dc.contributor.author | Jiménez Luna, Cristina | |
dc.contributor.author | Diéguez Castillo, Carmelo | |
dc.contributor.author | Martín, Ariadna | |
dc.contributor.author | Prados Salazar, José Carlos | |
dc.contributor.author | Martín Ruiz, José Luis | |
dc.contributor.author | Genilloud, Olga | |
dc.contributor.author | Vicente, Francisca | |
dc.contributor.author | Pérez del Palacio, José | |
dc.contributor.author | Caba Pérez, Octavio | |
dc.date.accessioned | 2021-10-18T12:02:09Z | |
dc.date.available | 2021-10-18T12:02:09Z | |
dc.date.issued | 2021 | |
dc.identifier.citation | Díaz, C.; Jiménez-Luna, C.; Diéguez-Castillo, C.; Martín, A.; Prados, J.; Martín-Ruíz, J.L.; Genilloud, O.; Vicente, F.; Palacio, J.P.d.; Caba, O. Untargeted Metabolomics for the Diagnosis of Exocrine Pancreatic Insufficiency in Chronic Pancreatitis. Medicina 2021, 57, 876. https://doi.org/10.3390/ medicina57090876 | es_ES |
dc.identifier.uri | http://hdl.handle.net/10481/70940 | |
dc.description.abstract | Background and Objectives: The clinical manifestations and course of chronic pancreatitis (CP) are often nonspecific and variable, hampering diagnosis of the risk of exocrine pancreatic insufficiency (EPI). Development of new, reproducible, and non-invasive methods to diagnose EPI is therefore a major priority. The objective of this metabolomic study was to identify novel biomarkers associated with EPI. Materials and Methods: We analyzed 53 samples from patients with CP, 32 with and 21 without EPI, using an untargeted metabolomics workflow based on hydrophilic interaction chromatography coupled to high-resolution mass spectrometry. Principal component and partial least squares-discriminant analyses showed significant between-group differentiation, and univariate and multivariate analyses identified potential candidate metabolites that significantly differed between samples from CP patients with EPI and those without EPI. Results: Excellent results were obtained using a six-metabolic panel to diagnose the presence of EPI in CP patients (area under the ROC curve = 0.785). Conclusions: This study confirms the usefulness of metabolomics in this disease setting, allowing the identification of novel biomarkers to differentiate between the presence and absence of EPI in CP patients. | es_ES |
dc.description.sponsorship | JUNTA DE ANDALUCIA, grants number PC-0498-2017 and PC-0549-2017 | es_ES |
dc.description.sponsorship | INSTITUTO DE SALUD CARLOS III, grant number DTS17/00081 | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | MDPI | es_ES |
dc.rights | Atribución 3.0 España | * |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
dc.subject | Metabolomics | es_ES |
dc.subject | Exocrine pancreatic insufficiency | es_ES |
dc.subject | Chronic pancreatitis | es_ES |
dc.subject | Biomarkers | es_ES |
dc.subject | Diagnosis | es_ES |
dc.subject | High-resolution mass spectrometry | es_ES |
dc.title | Untargeted Metabolomics for the Diagnosis of Exocrine Pancreatic Insufficiency in Chronic Pancreatitis | es_ES |
dc.type | journal article | es_ES |
dc.rights.accessRights | open access | es_ES |
dc.identifier.doi | 10.3390/medicina57090876 |