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dc.contributor.authorDonat Vargas, Carolina
dc.contributor.authorPérez Carrascosa, Francisco Miguel
dc.contributor.authorGómez Peña, Celia
dc.contributor.authorMustieles Miralles, Vicente
dc.contributor.authorSalcedo Bellido, Inmaculada 
dc.contributor.authorArrebola Moreno, Juan Pedro
dc.identifier.citationCarolina Donat-Vargas... [et al.]. Associations of serum phthalate metabolites with thyroid hormones in GraMo cohort, Southern Spain, Environmental Pollution, Volume 287, 2021, 117606, ISSN 0269-7491, []es_ES
dc.descriptionThese results would not have been achieved without the selfless collaboration of the staff from Santa Ana and San Cecilio Hospitals and the participants who took part in the study. Dr. JP Arrebola is under contract within the Ramon y Cajal Program (RYC-2016-20155, Ministerio de Economia, Industria y Competitividad, Spain) and Dr. C Donat-Vargas is under contract within the Atraccion de Talento (from the community of Madrid, Spain) . This study was supported by research grants from Instituto de Salud Carlos III (PI20/01568, PI16/01858) .es_ES
dc.description.abstractThe general population is continuously exposed to phthalates via various consumer products. Epidemiological research relating phthalate exposure to thyroid function during non-developmental periods is limited. This study aimed to investigate the associations between specific serum phthalate metabolites and indicators of thyroid function in adults. We measured 10 serum phthalate metabolites and thyroid hormones - total triiodothymnine (TT3), free thyroxine (FT4) and thyroid stimulating hormone (TSH) - in a subsample of 207 adults from the GraMo cohort. This subsample was made up of men and women (in equal proportions) of middle age (49 +/- 17 years) and from Southern Spain (province of Granada). Data on age, sex, body mass index, residence area, tobacco use, alcohol consumption and attained education were obtained from a questionnaire. Phthalate metabolites were log-transformed and categorized into tertiles. Cross-sectional associations of each metabolite with thyroid hormones were analyzed using multivariable-adjusted linear regression models. The mixture effect of metabolite phthalates was assessed using weighted quantile sum regression. After multivariable-adjustment, the following phthalate metabolites were significantly associated with TT3 in a dose-response manner: MMP (beta = 0.90: 95% confidence interval 0.68,1.12), MEP (beta = 0.67: 0.44, 0.90), MiBP (beta = 0.49: 0.21, 0.77), MiDP (beta = 0.27: 0.03, 0.52), MBzP (beta = 0.51: 0.28, 0.73), MEHP (beta = -0.59: -0.82, -0.35) and MiNP (beta = -0.43: -0.71, -0.14), when comparing highest vs. lowest exposed. The sum of all metabolites was also linked to FT4 levels. No significant associations were observed for TSH except for MiNP. Although phthalate metabolites with different molecular weight showed opposite associations, overall metabolite concentrations seem to associate with increased TT3 and FT4 serum levels. The cross-sectional nature of this analysis limits causal inference.es_ES
dc.description.sponsorshipRamon y Cajal Program (Ministerio de Economia, Industria y Competitividad, Spain) RYC-2016-20155es_ES
dc.description.sponsorshipInstituto de Salud Carlos III European Commission PI20/01568 PI16/01858es_ES
dc.rightsAtribución-NoComercial-SinDerivadas 3.0 España*
dc.subjectThyroid hormones es_ES
dc.subjectEndocrine disrupting chemicalses_ES
dc.subjectCross-sectional studyes_ES
dc.subjectCohort studyes_ES
dc.subjectEnvironmental epidemiologyes_ES
dc.subjectBiological sampleses_ES
dc.titleAssociations of serum phthalate metabolites with thyroid hormones in GraMo cohort, Southern Spaines_ES

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