Infant formula enriched with milk fat globule membrane, long-chain polyunsaturated fatty acids, synbiotics, gangliosides, nucleotides and sialic acid reduces infections during the first 18 months of life: The COGNIS study
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AuthorHerrmann, Florian; Nieto Ruiz, Ana María; Sepúlveda Valbuena, Natalia; Miranda León, María Teresa; Diéguez Castillo, Estefanía; Jiménez, Jesús; De Castellar, Roser; García Ricobaraza, María; García Santos, José Antonio; García Bermúdez, María Mercedes; Campoy Folgoso, Cristina
Early nutritionInfectionInfant formulaSynbioticsMilk fat globule membran
Herrmann, F., Nieto-Ruiz, A., Sepúlveda-Valbuena, N., Miranda, M. T., Diéguez, E., Jiménez, J., ... & Campoy, C. (2021). Infant formula enriched with milk fat globule membrane, long-chain polyunsaturated fatty acids, synbiotics, gangliosides, nucleotides and sialic acid reduces infections during the first 18 months of life: The COGNIS study. Journal of Functional Foods, 83, 104529.[10.1016/j.jff.2021.104529]
SponsorshipLaboratorios Ordesa, S.L.; COGNIS-team
Functional nutrients like synbiotics or milk-fat globule membrane (MFGM) affect positively host immunity, modifying intestinal microbioma and reducing early childhood infections. We compared effects of an experimental enriched-infant formula with long chain polyunsaturated fatty acids, MFGM, synbiotics, sialic acid, nucleotides and gangliosides to a standard infant formula and breastfeeding regarding infections incidence and evolution in infants until 18 months of age. 170 healthy infants were enrolled in a RCT to receive either a bioactive functional nutrients enriched infant formula (EF, n = 85) or a standard formula (SF, n = 85). 50 breastfed (BF) infants were also enrolled. At age 12 months, EF group compared to SF and BF groups showed a lower incidence of infectious episodes. Moreover, they also presented less incidence of respiratory tract infections and gastrointestinal infections than SF infants, reducing risk by 30.2% and 32.5%, respectively. Infants fed with an EF seem to have reduced incidence of certain infections at 12 months of age.