In Vitro Biodegradation Pattern of Collagen Matrices for Soft Tissue Augmentation
Metadatos
Mostrar el registro completo del ítemAutor
Vallecillo, Cristina; Toledano Osorio, Manuel; Vallecillo Rivas, Marta; Toledano Pérez, Manuel; Osorio Ruiz, RaquelEditorial
MDPI
Materia
Keratinized tissue Mucosal thickness Soft tissue graft Collagen matrices
Fecha
2021-08-07Referencia bibliográfica
Vallecillo, C... [et al.]. In Vitro Biodegradation Pattern of Collagen Matrices for Soft Tissue Augmentation. Polymers 2021, 13, 2633. [https://doi.org/10.3390/polym13162633]
Patrocinador
Ministry of Economy and Competitiveness; European Commission PID2020-114694RB-100 A-BIO-157-UGR-18/FEDER; University of Granada/Regional Government of Andalusia Research Fund from SpainResumen
Collagen matrices have become a great alternative to the use of connective tissue grafts
for soft tissue augmentation procedures. One of the main problems with these matrices is their
volume instability and rapid degradation. This study has been designed with the objective of
examining the degradation of three matrices over time. For this purpose, pieces of 10 10 mm2
of Fibro-Gide, Mucograft and Mucoderm were submitted to three different degradation tests—
(1) hydrolytic degradation in phosphate buffer solution (PBS); (2) enzyme resistance, using a 0.25%
porcine trypsin solution; and (3) bacterial collagenase resistance (Clostridium histolyticum)—over
different immersion periods of up to 50 days. Weight measurements were performed with an analytic
microbalance. Thickness was measured with a digital caliper. A stereomicroscope was used to obtain
the matrices’ images. ANOVA and Student–Newman–Keuls tests were used for mean comparisons
(p < 0.05), except when analyzing differences between time-points within the same matrix and
solution, where pair-wise comparisons were applied (p < 0.001). Fibro-Gide attained the highest
resistance to all degradation challenges. The bacterial collagenase solution was shown to constitute
the most aggressive test as all matrices presented 100% degradation before 14 days of storage.