Show simple item record

dc.contributor.authorRomero Garcia, Rafael
dc.contributor.authorGorriz Sáez, Juan Manuel
dc.identifier.citationRomero-Garcia, R.; Hart, M.G.; Bethlehem, R.A.I.; Mandal, A.; Assem, M.; Crespo-Facorro, B.; Gorriz, J.M.; Burke, G.A.A.; Price, S.J.; Santarius, T.; et al. BOLD Coupling between Lesioned and Healthy Brain Is Associated with Glioma Patients’ Recovery. Cancers 2021, 13, 5008. cancers13195008es_ES
dc.description.abstractGlioma, a type of brain tumour, affects not only the function of immediately adjacent brain tissue but also that in more distant areas, potentially impacting cognitive function after its surgical removal. Here, 17 patients with glioma had brain scans and tests of cognitive function during treatment and recovery. We investigated the effects of glioma on the brain, and what happens during recovery, using the brain’s “global signal” detected with magnetic resonance imaging (MRI). We found that the signal from gliomas was synchronised with the global signal in all patients and that this synchronisation was associated with the recovery of cognition after surgery. Specifically, patients with a greater reduction in glioma–global signal synchronisation following surgery were more likely to have a larger number of newly acquired cognitive difficulties. Together, these results suggest that the interaction between gliomas and the brain can predict how patients recover their cognitive abilities, which is important for their quality of life.es_ES
dc.description.abstractPredicting functional outcomes after surgery and early adjuvant treatment is difficult due to the complex, extended, interlocking brain networks that underpin cognition. The aim of this study was to test glioma functional interactions with the rest of the brain, thereby identifying the risk factors of cognitive recovery or deterioration. Seventeen patients with diffuse non-enhancing glioma (aged 22–56 years) were longitudinally MRI scanned and cognitively assessed before and after surgery and during a 12-month recovery period (55 MRI scans in total after exclusions). We initially found, and then replicated in an independent dataset, that the spatial correlation pattern between regional and global BOLD signals (also known as global signal topography) was associated with tumour occurrence. We then estimated the coupling between the BOLD signal from within the tumour and the signal extracted from different brain tissues. We observed that the normative global signal topography is reorganised in glioma patients during the recovery period. Moreover, we found that the BOLD signal within the tumour and lesioned brain was coupled with the global signal and that this coupling was associated with cognitive recovery. Nevertheless, patients did not show any apparent disruption of functional connectivity within canonical functional networks. Understanding how tumour infiltration and coupling are related to patients’ recovery represents a major step forward in prognostic development.es_ES
dc.description.sponsorshipGuarantors of Brain, Cancer Research UK Cambridge Centre, The Brain Tumour Charityes_ES
dc.description.sponsorshipEMERGIA Junta de Andalucia programes_ES
dc.description.sponsorshipRoyal Society Dorothy Hodgkin Research Fellowship (DHF130100)es_ES
dc.description.sponsorshipe Ciencia e Innovación (España)/FEDER under the RTI2018-098913-B100 project, by the Consejería de Economía, Innovación, Ciencia y Empleo (Junta de Andalucía) and FEDER under CV20-45250, A-TIC-080-UGR18, B-TIC-586-UGR20 and P20-00525 projectses_ES
dc.description.sponsorshipCambridge Trust—Yousef Jameel Scholarshipes_ES
dc.description.sponsorshipNIHR Cambridge Biomedical Research Centre (BRC-1215-20014)es_ES
dc.description.sponsorshipNational Institute for Health Research (NIHR)es_ES
dc.rightsAtribución 3.0 España*
dc.subjectGlobal signales_ES
dc.subjectBrain tumourses_ES
dc.subjectFunctional MRIes_ES
dc.subjectCognitive recoveryes_ES
dc.titleBOLD Coupling between Lesioned and Healthy Brain Is Associated with Glioma Patients’ Recoveryes_ES

Files in this item


This item appears in the following Collection(s)

Show simple item record

Atribución 3.0 España
Except where otherwise noted, this item's license is described as Atribución 3.0 España