Antimicrobial Effects of Potential Probiotics of Bacillus spp. Isolated from Human Microbiota: In Vitro and In Silico Methods
Metadatos
Mostrar el registro completo del ítemAutor
Torres Sánchez, Alfonso; Pardo Cacho, Jesús; López Moreno, Ana; Ruiz Moreno, Ángel; Cerk, Klara; Aguilera Gómez, MargaritaEditorial
MDPI
Materia
Probiotics Bacillus Antimicrobial effect In vitro methods In silico methods
Fecha
2021-07-29Referencia bibliográfica
Torres-Sánchez, A... [et al.]. Antimicrobial Effects of Potential Probiotics of Bacillus spp. Isolated from Human Microbiota: In Vitro and In Silico Methods. Microorganisms 2021, 9, 1615. [https://doi.org/10.3390/microorganisms9081615]
Patrocinador
European Commission IE_2019-198; OBEMIRISK EFSA GP/EFSA/ENCO/2018/03-GA04Resumen
The variable taxa components of human gut microbiota seem to have an enormous biotechnological
potential that is not yet well explored. To investigate the usefulness and applications of
its biocompounds and/or bioactive substances would have a dual impact, allowing us to better
understand the ecology of these microbiota consortia and to obtain resources for extended uses. Our
research team has obtained a catalogue of isolated and typified strains from microbiota showing
resistance to dietary contaminants and obesogens. Special attention was paid to cultivable Bacillus
species as potential next-generation probiotics (NGP) together with their antimicrobial production
and ecological impacts. The objective of the present work focused on bioinformatic genome data
mining and phenotypic analyses for antimicrobial production. In silico methods were applied over
the phylogenetically closest type strain genomes of the microbiota Bacillus spp. isolates and standardized
antimicrobial production procedures were used. The main results showed partial and
complete gene identification and presence of polyketide (PK) clusters on the whole genome sequences
(WGS) analysed. Moreover, specific antimicrobial effects against B. cereus, B. circulans, Staphylococcus
aureus, Streptococcus pyogenes, Escherichia coli, Serratia marcescens, Klebsiella spp., Pseudomonas spp., and
Salmonella spp. confirmed their capacity of antimicrobial production. In conclusion, Bacillus strains
isolated from human gut microbiota and taxonomic group, resistant to Bisphenols as xenobiotics type
endocrine disruptors, showed parallel PKS biosynthesis and a phenotypic antimicrobial effect. This
could modulate the composition of human gut microbiota and therefore its functionalities, becoming
a predominant group when high contaminant exposure conditions are present.