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dc.contributor.authorLondoño, Catalina
dc.contributor.authorSánchez Pérez, María José 
dc.date.accessioned2021-10-05T08:15:10Z
dc.date.available2021-10-05T08:15:10Z
dc.date.issued2021-08-04
dc.identifier.citationLondoño, C... [et al.]. Polyphenol Intake and Epithelial Ovarian Cancer Risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) Study. Antioxidants 2021, 10, 1249. [https://doi.org/10.3390/antiox10081249]es_ES
dc.identifier.urihttp://hdl.handle.net/10481/70642
dc.descriptionWe thank Bertrand Hemon for his valuable help with the EPIC database. We also thank the Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, and the National Institute for Public Health and the Environment (RIVM), Bilthoven, the Netherlands; Public Health Directorate, Asturias, Spain; the Oxford University, the Cambridge University, and the Imperial College of London, the UK, for their contribution and ongoing support to the EPIC Study. The authors also express their gratitude to all participants in the EPIC cohorts for their invaluable contribution to the study. This research was funded by the Women's Health Dexeus Foundation (R.Z.-R.). The coordination of EPIC is financially supported by the International Agency for Research on Cancer (IARC) and also by the Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, which has additional infrastructure support provided by the NIHR Imperial Biomedical Research Centre (BRC). The national cohorts are supported by: Danish Cancer Society (Denmark); Ligue Contre le Cancer, Institut Gustave Roussy, Mutuelle Generale de l'Education Nationale, Institut National de la Sante et de la Recherche Medicale (INSERM) (France); German Cancer Aid, German Cancer Research Center (DKFZ), German Institute of Human Nutrition Potsdam-Rehbruecke (DIfE), Federal Ministry of Education and Research (BMBF) (Germany); Associazione Italiana per la Ricerca sul Cancro-AIRC-Italy, Compagnia di SanPaolo and National Research Council (Italy); Dutch Ministry of Public Health, Welfare and Sports (VWS), Netherlands Cancer Registry (NKR), LK Research Funds, Dutch Prevention Funds, Dutch ZON (Zorg Onderzoek Nederland), World Cancer Research Fund (WCRF), Statistics Netherlands (The Netherlands); Health Research Fund (FIS)-Instituto de Salud Carlos III (ISCIII), Regional Governments of Andalucia, Asturias, Basque Country, Murcia and Navarra, and the Catalan Institute of Oncology-ICO (Spain); Swedish Cancer Society, Swedish Research Council and County Councils of Skane and Vasterbotten (Sweden); Cancer Research UK (14136 to EPIC-Norfolk; C8221/A29017 to EPIC-Oxford), Medical Research Council (1000143 to EPIC-Norfolk; MR/M012190/1 to EPIC-Oxford) (United Kingdom). We thank CERCA Program/Generalitat de Catalunya for institutional support. R.Z.-R. would like to thank the "Miguel Servet" program (CPII20/00009) from the Institute of Health Carlos III (Spain) and the European Social Fund (ESF).es_ES
dc.description.abstractDespite some epidemiological evidence on the protective effects of polyphenol intake on epithelial ovarian cancer (EOC) risk from case-control studies, the evidence is scarce from prospective studies and non-existent for several polyphenol classes. Therefore, we aimed to investigate the associations between the intake of total, classes and subclasses of polyphenols and EOC risk in a large prospective study. The study was conducted in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort, which included 309,129 adult women recruited mostly from the general population. Polyphenol intake was assessed through validated country-specific dietary questionnaires and the Phenol-Explorer database. During a mean follow-up of 14 years, 1469 first incident EOC cases (including 806 serous, 129 endometrioid, 102 mucinous, and 67 clear cell tumours) were identified. In multivariable-adjusted Cox regression models, the hazard ratio in the highest quartile of total polyphenol intake compared with the lowest quartile (HRQ4vsQ1) was 1.14 (95% CI 0.94–1.39; p-trend = 0.11). Similarly, the intake of most classes and subclasses of polyphenols were not related to either overall EOC risk or any EOC subtype. A borderline statistically significant positive association was observed between phenolic acid intake (HRQ4vsQ1 = 1.20, 95% CI 1.01–1.43; p-trend = 0.02) and EOC risk, especially for the serous subtype and in women with obesity, although these associations did not exceed the Bonferroni correction threshold. The current results do not support any association between polyphenol intake and EOC in our large European prospective study. Results regarding phenolic acid intake need further investigationes_ES
dc.description.sponsorshipJulius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrechtes_ES
dc.description.sponsorshipNational Institute for Public Health and the Environment (RIVM), Bilthoven, the Netherlandses_ES
dc.description.sponsorshipPublic Health Directorate, Asturias, Spaines_ES
dc.description.sponsorshipOxford Universityes_ES
dc.description.sponsorshipWorld Health Organizationes_ES
dc.description.sponsorshipNIHR Imperial Biomedical Research Centre (BRC)es_ES
dc.description.sponsorshipDanish Cancer Societyes_ES
dc.description.sponsorshipLigue nationale contre le canceres_ES
dc.description.sponsorshipInstitut Gustave Roussyes_ES
dc.description.sponsorshipMutuelle Generale de l'Education Nationalees_ES
dc.description.sponsorshipInstitut National de la Sante et de la Recherche Medicale (Inserm)es_ES
dc.description.sponsorshipDeutsche Krebshilfe Helmholtz Association Federal Ministry of Education & Research (BMBF)es_ES
dc.description.sponsorshipFondazione AIRC per la ricerca sul cancroes_ES
dc.description.sponsorshipConsiglio Nazionale delle Ricerche (CNR)es_ES
dc.description.sponsorshipDutch Ministry of Public Health, Welfare and Sports (VWS), Netherlands Cancer Registry (NKR), LK Research Funds Dutch Prevention Funds Netherlands Organization for Scientific Research (NWO) World Cancer Research Fund (WCRF), Statistics Netherlandses_ES
dc.description.sponsorshipHealth Research Fund (FIS)-Instituto de Salud Carlos III (ISCIII)es_ES
dc.description.sponsorshipSwedish Cancer Society Swedish Research Counciles_ES
dc.description.sponsorshipEuropean Commissiones_ES
dc.description.sponsorshipVasterbotten (Sweden)es_ES
dc.description.sponsorshipCancer Research UK 14136 C8221/A29017es_ES
dc.description.sponsorshipUK Research & Innovation (UKRI) Medical Research Council UK (MRC)es_ES
dc.description.sponsorshipEuropean Commission 1000143 MR/M012190/1es_ES
dc.description.sponsorshipCERCA Program/Generalitat de Catalunya CPII20/00009 Instituto de Salud Carlos IIIes_ES
dc.description.sponsorshipEuropean Social Fund (ESF)es_ES
dc.description.sponsorshipUniversity of Cambridgees_ES
dc.description.sponsorshipImperial College of London, the UKes_ES
dc.description.sponsorshipWomen's Health Dexeus Foundationes_ES
dc.language.isoenges_ES
dc.publisherMDPIes_ES
dc.rightsAtribución 3.0 España*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es/*
dc.subjectOvarian canceres_ES
dc.subjectPolyphenolses_ES
dc.subjectFlavonoids es_ES
dc.subjectIntakees_ES
dc.subjectCohortes_ES
dc.subjectEPICes_ES
dc.titlePolyphenol Intake and Epithelial Ovarian Cancer Risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) Studyes_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES
dc.identifier.doi10.3390/antiox10081249
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersiones_ES


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Atribución 3.0 España
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