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dc.contributor.authorPlaza Florido, Abel Adrián 
dc.contributor.authorAltmae, Signe 
dc.contributor.authorOrtega Porcel, Francisco Bartolomé 
dc.date.accessioned2021-10-04T08:17:43Z
dc.date.available2021-10-04T08:17:43Z
dc.date.issued2021-08-01
dc.identifier.citationPlaza-Florido, A... [et al.]. Cardiorespiratory fitness in children with overweight/obesity: Insights into the molecular mechanisms. Scand J Med Sci Sports. 2021; 00: 1– 9. [https://doi.org/10.1111/sms.14028]es_ES
dc.identifier.urihttp://hdl.handle.net/10481/70601
dc.descriptionSpanish Ministry of Economy and Competitiveness, Grant/Award Number: DEP2013--47540, DEP2016-79512--R and DEP2017--91544--EXP; Spanish Ministry of Economy, Industry and Competitiveness (MINECO); European Regional Development Fund (FEDER), Grant/Award Number: RYC--2016--21199 and ENDORE SAF2017--87526--R; Junta de Andalucia, Grant/Award Number: BIO--302 and US--1254251; University of Jaen, Grant/Award Number: PAIUJA--EI_CTS02; Spanish Ministry of Education, Culture and Sport, Grant/Award Number: FPU 16/02760; NIH, Grant/Award Number:UO1 TR002004; PERC Systems Biology Fund; Unit of Excellence on EXERNET Research Network on Exercise and Health in Special Populations; Alicia Koplowitz Foundation; Henning Och Johan Throne--Holsts Stiftelse Grant; University of Granada, Plan Propio de Investigacion 2016, Excellence actions: Units of Excellence; Unit of Excellence on Exercise and Health (UCEES); Junta de Andalucia, Consejeria de Conocimiento, Investigacion y Universidades and European Regional Development Fund (ERDF), Grant/Award Number: SOMM17/6107/UGR; European Regional Development Funds, Grant/Award Number: B--CTS-355--UGR18 and B--CTS--500--UGR18; Funding for open access charge: Universidad de Granada/CBUAes_ES
dc.description.abstractObjectives: High cardiorespiratory fitness (CRF) levels reduce the risk of developing cardiovascular disease (CVD) during adulthood. However, little is known about the molecular mechanisms underlying the health benefits of high CRF levels at the early stage of life. This study aimed to analyze the whole-blood transcriptome profile of fit children with overweight/obesity (OW/OB) compared to unfit children with OW/OB. Design: 27 children with OW/OB (10.14 ± 1.3 years, 59% boys) from the ActiveBrains project were evaluated. VO2peak was assessed using a gas analyzer, and participants were categorized into fit or unfit according to the CVD risk-related cut-points. Whole-blood transcriptome profile (RNA sequencing) was analyzed. Differential gene expression analysis was performed using the limma R/Bioconductor software package (analyses adjusted by sex and maturational status), and pathways’ enrichment analysis was performed with DAVID. In addition, in silico validation data mining was performed using the PHENOPEDIA database. Results: 256 genes were differentially expressed in fit children with OW/OB compared to unfit children with OW/OB after adjusting by sex and maturational status (FDR < 0.05). Enriched pathway analysis identified gene pathways related to inflammation (eg, dopaminergic and GABAergic synapse pathways). Interestingly, in silico validation data mining detected a set of the differentially expressed genes to be related to CVD, metabolic syndrome, hypertension, inflammation, and asthma. Conclusion: The distinct pattern of whole-blood gene expression in fit children with OW/OB reveals genes and gene pathways that might play a role in reducing CVD risk factors later in life.es_ES
dc.description.sponsorshipSpanish Ministry of Economy and Competitiveness DEP2013-47540 DEP2016-79512-R DEP2017-91544-EXPes_ES
dc.description.sponsorshipSpanish Ministry of Economy, Industry and Competitiveness (MINECO)es_ES
dc.description.sponsorshipEuropean Commission RYC-2016-21199es_ES
dc.description.sponsorshipENDORE SAF2017-87526-Res_ES
dc.description.sponsorshipJunta de Andalucia BIO-302 US-1254251es_ES
dc.description.sponsorshipUniversity of Jaen PAIUJA-EI_CTS02es_ES
dc.description.sponsorshipSpanish Ministry of Education, Culture and Sport FPU 16/02760es_ES
dc.description.sponsorshipUnited States Department of Health & Human Serviceses_ES
dc.description.sponsorshipNational Institutes of Health (NIH) - USA UO1 TR002004es_ES
dc.description.sponsorshipPERC Systems Biology Fundes_ES
dc.description.sponsorshipUnit of Excellence on EXERNET Research Network on Exercise and Health in Special Populationses_ES
dc.description.sponsorshipAlicia Koplowitz Foundationes_ES
dc.description.sponsorshipHenning Och Johan Throne-Holsts Stiftelse Grantes_ES
dc.description.sponsorshipUniversity of Granadaes_ES
dc.description.sponsorshipUnit of Excellence on Exercise and Health (UCEES)es_ES
dc.description.sponsorshipJunta de Andalucia, Consejeria de Conocimiento, Investigacion y Universidades and European Regionales_ES
dc.description.sponsorshipDevelopment Fund (ERDF) SOMM17/6107/UGR European Commission B-CTS-355-UGR18 B-CTS-500-UGR18es_ES
dc.description.sponsorshipUniversidad de Granada/CBUAes_ES
dc.language.isoenges_ES
dc.publisherWiley-Blackwell Publishinges_ES
dc.rightsAtribución 3.0 España*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es/*
dc.subjectAerobic fitnesses_ES
dc.subjectChildhoodes_ES
dc.subjectGene expressiones_ES
dc.subjectRNA-Seqes_ES
dc.subjectTranscriptomees_ES
dc.titleCardiorespiratory fitness in children with overweight/obesity: Insights into the molecular mechanismses_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES
dc.identifier.doi10.1111/sms.14028
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersiones_ES


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