Study of the Antimicrobial Effect of an Ethanolic Extract of Propolis in Periodontal Disease
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Lisbona González, María Jesús; Muñoz Soto, Esther; Reyes Botella, Candelaria; Olmedo Gaya, María Victoria; Díaz Castro, Javier; Moreno Fernández, JorgeEditorial
MDPI
Materia
Propolis Oral healing Periodontal disease Antimicrobial effectiveness
Date
2021Referencia bibliográfica
Lisbona-González, M.J.; Muñoz-Soto, E.; Reyes-Botella, C.; Olmedo-Gaya, M.V.; Diaz-Castro, J.; Moreno-Fernandez, J. Study of the Antimicrobial Effect of an Ethanolic Extract of Propolis in Periodontal Disease. Appl. Sci. 2021, 11, 7463. https://doi.org/10.3390/app11167463
Abstract
Periodontal disease encompasses gingivitis and periodontitis and is one of the most
common chronic infections in the adult population. This study aimed to evaluate the influence of
Spanish propolis extract (EEP) on the effect of the clinical and microbiological parameters as an
adjuvant to scaling and root planning in patients undergoing supportive periodontal therapy (SPT).
Forty chronic periodontitis patients were randomly assigned into two groups for the treatment. In
the control group (n = 20), the sites were treated by scaling and root planing followed by gingival
irrigation with physiological saline and in the test group (n = 20), the sites were treated by scaling and
root planing followed by subgingival placement of EEP. At baseline (BL), bleeding on probing positive
(BOP+) sites with probing pocket (PPD) ≥ 4 mm were defined as study sites. Plaque index, PPD, BOP,
clinical attachment level (CAL), and subgingival plaque were evaluated at BL and 1 month later. The
results showed a significant clinical improvement (p < 0.05) in the PPD, CAL and BOP+ comparing
them with BL and one month after the periodontal treatment and a significant reduction (p < 0.05) for
Tannerella forsythensis, Porphyromonas gingivalis, Prevotella intermedia and Treponema denticola in both
groups. In addition, the improvement of clinical parameters was observed with subgingival use of
EEP and also statistically significant differences between groups were observed (p < 0.05) such as
reductions of BOP+ % and reduced counts of T. forsythensis and P. gingivalis, considered as the “key
pathogens” for the periodontal diseases. Our results suggest prophylactic and therapeutic potential
for EEP against periodontal diseases, improving clinical parameters, reducing gingival bleeding and
decreasing bacterial counts of T. forsythensis and P. gingivalis. The subgingival use of EEP represents a
promising modality as an adjuvant in periodontal therapy to avoid microbial resistance and other
adverse effects.